PDF(Pubmed)
Abstract：
Introduction: Behaviors of swimming rodents are not uniform, exhibiting large variations, which may underlie the individual differences in swimming exercise-induced benefits. The study aimed to monitor individualized swimming behavior and evaluate its biological significance. Methods: A swimming tank which can monitor individualized rodent swimming behavior during exercise was established. A total of 45 mice were subjected to swimming training for 1 month (1 h per day) and the swimming behaviors of each mouse were recorded. Results: The swimming behaviors of mice displayed considerable variations in aspects of distance, velocity, and area preference. For example, nearly one-third of mice preferred to swim in central area and most of the mice exhibited an even area distribution. Long-term exercise training improved cardiac systolic function and decreased blood pressure in mice, but hardly changed swimming behaviors. Analyses of the relationship between swimming behavior and cardiovascular adaptations to exercise training revealed that swimming behavior indicated the biological effects of swimming training. Specifically, mice which preferred swimming at the central zone or were trainable in behavior during 1-month training exhibited better outcomes in cardiac function and blood pressure post long-term exercise. Mechanistically, a centralized swimming behavior indicated a smaller stress during exercise, as evidenced by a milder activation of hypothalamic-pituitary-adrenal axis. Discussion: These results suggest that swimming behavior during training indicates individualized adaptations to long-term exercise, and highlight a biological significance of swimming behavior monitoring in animal studies.
摘要：
简介：游泳啮齿动物的行为不均匀，表现出巨大的变化，这可能是游泳运动引起的益处的个体差异的基础。该研究旨在监测个性化游泳行为并评估其生物学意义。方法：建立一个可监测啮齿动物运动过程中个性化游泳行为的游泳池。对45只小鼠进行游泳训练1个月(每天1小时),记录每只小鼠的游泳行为。结果：小鼠的游泳行为在距离方面表现出相当大的差异，速度,和区域偏好。例如,近三分之一的小鼠更喜欢在中心区域游泳，大多数小鼠表现出均匀的区域分布。长期运动训练改善小鼠心脏收缩功能，降低血压，但游泳行为几乎没有改变.对游泳行为与心血管对运动训练的适应之间的关系进行分析，发现游泳行为表明了游泳训练的生物学效应。具体来说,喜欢在中心区游泳或在1个月训练中接受行为训练的小鼠在长期运动后表现出更好的心脏功能和血压结果.机械上,集中的游泳行为表明运动过程中的压力较小，下丘脑-垂体-肾上腺轴的激活更为温和。讨论：这些结果表明，训练期间的游泳行为表明对长期运动的个性化适应，并强调了动物研究中游泳行为监测的生物学意义。
