Abstract：
BACKGROUND: Pericardial effusion is associated with amyloidosis, specifically amyloid light chain (AL) and transthyretin (ATTR) subtypes. However, the patients might present with different clinical symptoms.
OBJECTIVE: To determine the characteristics and associations of patients with pericardial effusion owing to either AL or ATTR amyloidosis.
METHODS: This study reviewed 26 studies from databases such as PubMed, MEDLINE, Web of Science, Google Scholar and CINAHL databases after protocol registration. The data were analyzed in IBM SPSS 21. Many statistical tests, such as Student t- and the Mann-Whitney U tests, were used. Multivariate logistic regression analysis was also performed. A p-value< 0.05 was considered significant.
RESULTS: A total of 531 patients with pericardial effusion secondary to amyloidosis were included. The mean age was 58.4±24.5 years. Most of the patients were male (72.9%). Common co-morbid conditions included hypertension (16.8%) and active smoking (12.9%). The most common time from symptom onset to the clinical presentation was less than 1 week (45%). ATTR amyloidosis was more common in older patients (p<0.05). Abdominal and chest discomfort were commonly associated with AL and ATTR amyloidosis, respectively (p<0.05). Patients with AL amyloidosis had a higher association with interventricular septal thickening and increased posterior wall thickness (p<0.05). First-degree atrioventricular block, left bundle branch block (LBBB), and atrial fibrillation (AF) were more associated with ATTR amyloidosis (p<0.05).
CONCLUSIONS: Pericardial effusion in patients with AL amyloidosis was associated with hypertrophic remodeling, while conduction abnormalities were associated with ATTR amyloidosis.
OBJECTIVE: To determine the characteristics and associations of patients with pericardial effusion owing to either AL or ATTR amyloidosis.
METHODS: This study reviewed 26 studies from databases such as PubMed, MEDLINE, Web of Science, Google Scholar and CINAHL databases after protocol registration. The data were analyzed in IBM SPSS 21. Many statistical tests, such as Student t- and the Mann-Whitney U tests, were used. Multivariate logistic regression analysis was also performed. A p-value< 0.05 was considered significant.
RESULTS: A total of 531 patients with pericardial effusion secondary to amyloidosis were included. The mean age was 58.4±24.5 years. Most of the patients were male (72.9%). Common co-morbid conditions included hypertension (16.8%) and active smoking (12.9%). The most common time from symptom onset to the clinical presentation was less than 1 week (45%). ATTR amyloidosis was more common in older patients (p<0.05). Abdominal and chest discomfort were commonly associated with AL and ATTR amyloidosis, respectively (p<0.05). Patients with AL amyloidosis had a higher association with interventricular septal thickening and increased posterior wall thickness (p<0.05). First-degree atrioventricular block, left bundle branch block (LBBB), and atrial fibrillation (AF) were more associated with ATTR amyloidosis (p<0.05).
CONCLUSIONS: Pericardial effusion in patients with AL amyloidosis was associated with hypertrophic remodeling, while conduction abnormalities were associated with ATTR amyloidosis.
摘要：
背景：心包积液与淀粉样变性有关，特别是淀粉样蛋白轻链（AL）和甲状腺素运载蛋白（ATTR）亚型。然而,患者可能会出现不同的临床症状。
目的：确定AL或ATTR淀粉样变性心包积液患者的特征和相关性。
方法：本研究回顾了来自PubMed、MEDLINE,WebofScience,协议注册后的谷歌学者和CINAHL数据库。数据在IBMSPSS一21中进行分析。许多统计测试，比如学生-和曼-惠特尼U测试，被使用。同时进行多因素logistic回归分析。P值<0.05被认为是显著的。
结果：共纳入531例淀粉样变性心包积液患者。平均年龄为58.4±24.5岁。大多数患者为男性（72.9%）。常见的合并症包括高血压（16.8%）和主动吸烟（12.9%）。从症状发作到临床表现的最常见时间少于1周（45％）。ATTR淀粉样变性在老年患者中更为常见(p<0.05)。腹部和胸部不适通常与AL和ATTR淀粉样变性相关，分别为(p<0.05)。AL淀粉样变性患者与室间隔增厚和后壁厚度增加的相关性更高(p<0.05)。一级房室传导阻滞,左束支传导阻滞（LBBB），心房颤动（AF）与ATTR淀粉样变性的相关性更高（p<0.05）。
结论：AL淀粉样变性患者的心包积液与肥厚性重塑有关，而传导异常与ATTR淀粉样变相关。
目的：确定AL或ATTR淀粉样变性心包积液患者的特征和相关性。
方法：本研究回顾了来自PubMed、MEDLINE,WebofScience,协议注册后的谷歌学者和CINAHL数据库。数据在IBMSPSS一21中进行分析。许多统计测试，比如学生-和曼-惠特尼U测试，被使用。同时进行多因素logistic回归分析。P值<0.05被认为是显著的。
结果：共纳入531例淀粉样变性心包积液患者。平均年龄为58.4±24.5岁。大多数患者为男性（72.9%）。常见的合并症包括高血压（16.8%）和主动吸烟（12.9%）。从症状发作到临床表现的最常见时间少于1周（45％）。ATTR淀粉样变性在老年患者中更为常见(p<0.05)。腹部和胸部不适通常与AL和ATTR淀粉样变性相关，分别为(p<0.05)。AL淀粉样变性患者与室间隔增厚和后壁厚度增加的相关性更高(p<0.05)。一级房室传导阻滞,左束支传导阻滞（LBBB），心房颤动（AF）与ATTR淀粉样变性的相关性更高（p<0.05）。
结论：AL淀粉样变性患者的心包积液与肥厚性重塑有关，而传导异常与ATTR淀粉样变相关。
