PDF(Pubmed)
Abstract：
UNASSIGNED: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has broad tissue tropism and high transmission, which are likely to perpetuate the pandemic. The study aim to analyze the clinicopathogenic characteristics in paediatric patients.
UNASSIGNED: In this single-centre study, we retrospectively included all confirmed cases infected by SARS-CoV-2 infection at Xi\'an Children\'s Hospital, China, from 1 December to 31 December 2022. The demographic, clinical, laboratory, and radiological features of the patients were analysed.
UNASSIGNED: A total of 4,520 paediatric patients with SARS-CoV-2 omicron variant infections were included. Of these, 3,861 (85.36%) were outpatients, 659 (14.64%) were hospitalised patients, and nine patients (0.20%) died. Of the nine patients who died, five were diagnosed with acute necrotising encephalopathy (ANE). The most common symptoms were fever in 4,275 (94.59%) patients, cough in 1,320 (29.20%) patients, convulsions in 610 (13.50%) patients, vomiting in 410 (9.07%) patients, runny nose/coryza in 277 (6.13%) patients, hoarseness of voice in 273 (6.04%) patients. A blood cell analysis showed a slight elevation of monocytes (mean: 11.14 ± 0.07%). The main diagnoses for both outpatients and inpatients were respiratory infection with multisystem manifestations.
UNASSIGNED: A high incidence of convulsions is a typical characteristic of children infected with SARS-CoV-2. Five of the nine COVID-19 fatalities were associated with ANE. This indicates that nervous system damage in children with SARS-CoV-2 infection is more significant.
UNASSIGNED: In this single-centre study, we retrospectively included all confirmed cases infected by SARS-CoV-2 infection at Xi\'an Children\'s Hospital, China, from 1 December to 31 December 2022. The demographic, clinical, laboratory, and radiological features of the patients were analysed.
UNASSIGNED: A total of 4,520 paediatric patients with SARS-CoV-2 omicron variant infections were included. Of these, 3,861 (85.36%) were outpatients, 659 (14.64%) were hospitalised patients, and nine patients (0.20%) died. Of the nine patients who died, five were diagnosed with acute necrotising encephalopathy (ANE). The most common symptoms were fever in 4,275 (94.59%) patients, cough in 1,320 (29.20%) patients, convulsions in 610 (13.50%) patients, vomiting in 410 (9.07%) patients, runny nose/coryza in 277 (6.13%) patients, hoarseness of voice in 273 (6.04%) patients. A blood cell analysis showed a slight elevation of monocytes (mean: 11.14 ± 0.07%). The main diagnoses for both outpatients and inpatients were respiratory infection with multisystem manifestations.
UNASSIGNED: A high incidence of convulsions is a typical characteristic of children infected with SARS-CoV-2. Five of the nine COVID-19 fatalities were associated with ANE. This indicates that nervous system damage in children with SARS-CoV-2 infection is more significant.
摘要：
■严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）具有广泛的组织嗜性和高传播性，这很可能会延续大流行。本研究旨在分析儿科患者的临床病理特征。
■在这项单中心研究中，我们回顾性地纳入了西安市儿童医院所有感染SARS-CoV-2的确诊病例，中国,2022年12月1日至12月31日。人口统计，临床,实验室,并分析了患者的放射学特征。
■共纳入了4,520名SARS-CoV-2omicron变异型感染的儿科患者。其中,门诊病人3,861人(85.36%),659名（14.64%）住院患者，9名患者(0.20%)死亡。在死亡的九名患者中，5例患者被诊断为急性坏死性脑病（ANE）。最常见的症状是4,275例(94.59%)患者发热,1320名(29.20%)患者咳嗽，610例(13.50%)患者出现抽搐,410例(9.07%)病人呕吐,277例(6.13%)患者流鼻涕/鼻炎，273例(6.04%)患者声音嘶哑。血细胞分析显示单核细胞略有升高(平均值:11.14±0.07%)。门诊和住院患者的主要诊断为呼吸道感染，多系统表现。
■惊厥的高发生率是感染SARS-CoV-2的儿童的典型特征。9例COVID-19死亡病例中有5例与ANE有关。这表明SARS-CoV-2感染患儿的神经系统损害更为显著。
■在这项单中心研究中，我们回顾性地纳入了西安市儿童医院所有感染SARS-CoV-2的确诊病例，中国,2022年12月1日至12月31日。人口统计，临床,实验室,并分析了患者的放射学特征。
■共纳入了4,520名SARS-CoV-2omicron变异型感染的儿科患者。其中,门诊病人3,861人(85.36%),659名（14.64%）住院患者，9名患者(0.20%)死亡。在死亡的九名患者中，5例患者被诊断为急性坏死性脑病（ANE）。最常见的症状是4,275例(94.59%)患者发热,1320名(29.20%)患者咳嗽，610例(13.50%)患者出现抽搐,410例(9.07%)病人呕吐,277例(6.13%)患者流鼻涕/鼻炎，273例(6.04%)患者声音嘶哑。血细胞分析显示单核细胞略有升高(平均值:11.14±0.07%)。门诊和住院患者的主要诊断为呼吸道感染，多系统表现。
■惊厥的高发生率是感染SARS-CoV-2的儿童的典型特征。9例COVID-19死亡病例中有5例与ANE有关。这表明SARS-CoV-2感染患儿的神经系统损害更为显著。
