PDF(Pubmed)
Abstract：
UNASSIGNED: Childhood obesity has become a prominent issue in the society, which can lead to left ventricular remodeling and severe cardiovascular complications in adulthood. It is beneficial to identify the causes of left ventricular remodeling so that targeted measures can be taken to prevent the cardiovascular disease. Therefore, this study aimed to explore the relationship between left ventricular remodeling and changes in blood lipid indexes in obese children.
UNASSIGNED: This study was conducted on 40 healthy non-obese children and 140 obese children diagnosed in the pediatric health department of our hospital. Clinical data collected from the two groups were compared. Echocardiography was performed to examine left ventricular configuration and cardiac function. Multiple linear regression analysis was conducted to assess the independent effects of blood lipid levels on echocardiographic parameters. Blood lipid indicators among different left ventricular structural patterns which were classified according to left ventricular mass indexes and relative wall thickness were compared.
UNASSIGNED: Obese children exhibited significantly increased height, weight, body mass index (BMI), body fat percentage (BFP), blood pressure, triglycerides, total cholesterol, left ventricular internal diameter (LVIDd), interventricular septum (IVSd), left ventricular posterior wall diastolic thickness (LVPWd), myocardial mass (LVM) and relative wall thickness (RWT), as well as lower high-density lipoprotein cholesterol (HDL-C) and left ventricular ejection fraction (LVEF) compared to the non-obese children (P < 0.05). Multiple linear correlation analysis showed LVM had a significantly positive correlation with BMI (r = 3.21, P = 0.002) and SBP (r = 2.61, P = 0.01); LVMI had a significantly negative correlation with HDL-C (r = -2.45, P = 0.015); RWT had a significantly positive correlation with SBP (r = 2.50, P = 0.013) but a significantly negative correlation with HDL-C (r = -2.35, P = 0.02). Furthermore, there were significant differences in HDL-C values among children with different ventricular configurations (P < 0.05), with the lowest HDL-C value recorded in the concentric hypertrophy group.
UNASSIGNED: Obese children will develop left ventricular remodeling. The left ventricular configuration indexes are most significantly associated with serum HDL-C. Lower HDL-C level contributes to severer left ventricular hypertrophy, indicating a concentric hypertrophy pattern.
UNASSIGNED: This study was conducted on 40 healthy non-obese children and 140 obese children diagnosed in the pediatric health department of our hospital. Clinical data collected from the two groups were compared. Echocardiography was performed to examine left ventricular configuration and cardiac function. Multiple linear regression analysis was conducted to assess the independent effects of blood lipid levels on echocardiographic parameters. Blood lipid indicators among different left ventricular structural patterns which were classified according to left ventricular mass indexes and relative wall thickness were compared.
UNASSIGNED: Obese children exhibited significantly increased height, weight, body mass index (BMI), body fat percentage (BFP), blood pressure, triglycerides, total cholesterol, left ventricular internal diameter (LVIDd), interventricular septum (IVSd), left ventricular posterior wall diastolic thickness (LVPWd), myocardial mass (LVM) and relative wall thickness (RWT), as well as lower high-density lipoprotein cholesterol (HDL-C) and left ventricular ejection fraction (LVEF) compared to the non-obese children (P < 0.05). Multiple linear correlation analysis showed LVM had a significantly positive correlation with BMI (r = 3.21, P = 0.002) and SBP (r = 2.61, P = 0.01); LVMI had a significantly negative correlation with HDL-C (r = -2.45, P = 0.015); RWT had a significantly positive correlation with SBP (r = 2.50, P = 0.013) but a significantly negative correlation with HDL-C (r = -2.35, P = 0.02). Furthermore, there were significant differences in HDL-C values among children with different ventricular configurations (P < 0.05), with the lowest HDL-C value recorded in the concentric hypertrophy group.
UNASSIGNED: Obese children will develop left ventricular remodeling. The left ventricular configuration indexes are most significantly associated with serum HDL-C. Lower HDL-C level contributes to severer left ventricular hypertrophy, indicating a concentric hypertrophy pattern.
摘要：
■儿童肥胖已成为社会上一个突出的问题，这可能导致成年后左心室重构和严重的心血管并发症。明确左心室重构的原因,可以采取针对性的措施预防心血管疾病的发生。因此,本研究旨在探讨肥胖儿童左心室重构与血脂指标变化的关系。
■这项研究是对在我院儿科卫生部门诊断的40名健康非肥胖儿童和140名肥胖儿童进行的。比较两组患者的临床资料。进行超声心动图检查左心室构型和心功能。进行了多元线性回归分析，以评估血脂水平对超声心动图参数的独立影响。比较不同左心室结构模式之间的血脂指标，并根据左心室质量指数和相对壁厚进行分类。
■肥胖儿童表现出明显的身高增加，体重,体重指数（BMI），体脂百分比（BFP），血压,甘油三酯，总胆固醇,左心室内径(LVIDd),室间隔(IVSd),左心室后壁舒张厚度（LVPWd），心肌质量（LVM）和相对壁厚（RWT），与非肥胖儿童相比，高密度脂蛋白胆固醇（HDL-C）和左心室射血分数（LVEF）降低（P<0.05）。多元线性相关分析显示,LVM与BMI(r=3.21,P=0.002)、SBP(r=2.61,P=0.01)呈显著正相关;LVMI与HDL-C呈显著负相关(r=-2.45,P=0.015);RWT与SBP呈显著正相关(r=2.50,P=0.013),与HDL-C呈显著负相关(r=0.02=-2.35,P此外，不同心室构型患儿HDL-C值差异有统计学意义(P<0.05),与最低的HDL-C值记录在同心肥大组。
■肥胖儿童会发生左心室重构。左心室构型指数与血清HDL-C最显著相关。较低的HDL-C水平有助于严重的左心室肥厚，表明同心肥大模式。
■这项研究是对在我院儿科卫生部门诊断的40名健康非肥胖儿童和140名肥胖儿童进行的。比较两组患者的临床资料。进行超声心动图检查左心室构型和心功能。进行了多元线性回归分析，以评估血脂水平对超声心动图参数的独立影响。比较不同左心室结构模式之间的血脂指标，并根据左心室质量指数和相对壁厚进行分类。
■肥胖儿童表现出明显的身高增加，体重,体重指数（BMI），体脂百分比（BFP），血压,甘油三酯，总胆固醇,左心室内径(LVIDd),室间隔(IVSd),左心室后壁舒张厚度（LVPWd），心肌质量（LVM）和相对壁厚（RWT），与非肥胖儿童相比，高密度脂蛋白胆固醇（HDL-C）和左心室射血分数（LVEF）降低（P<0.05）。多元线性相关分析显示,LVM与BMI(r=3.21,P=0.002)、SBP(r=2.61,P=0.01)呈显著正相关;LVMI与HDL-C呈显著负相关(r=-2.45,P=0.015);RWT与SBP呈显著正相关(r=2.50,P=0.013),与HDL-C呈显著负相关(r=0.02=-2.35,P此外，不同心室构型患儿HDL-C值差异有统计学意义(P<0.05),与最低的HDL-C值记录在同心肥大组。
■肥胖儿童会发生左心室重构。左心室构型指数与血清HDL-C最显著相关。较低的HDL-C水平有助于严重的左心室肥厚，表明同心肥大模式。
