PDF(Pubmed)
Abstract：
Despite the fact that pneumonia remains a leading cause of mortality and morbidity in pre-weaned calves, relatively little is known regarding the effects of the concurrent administration of intranasal pneumonia virus vaccines, particularly in calves with high levels of maternally derived antibodies. The objective of this study was to use a cohort of 40 dairy and dairy-beef female and male calves (27 females and 13 males) to determine serological responses to concurrent administration at 3 weeks of age (22 ± 4.85 days) of two commercially available intranasal (IN) vaccines for the viruses: bovine respiratory syncytial virus (BRSV), bovine herpes virus 1 (BoHV-1), and parainfluenza-3-virus (PI3-V). The study groups were as follows: (i) Bovilis IBR Marker Live only® (IO), (ii) Bovilis INtranasal RSP Live® only (RPO), (iii) Concurrent vaccination with Bovilis IBR Marker Live® & Bovilis Intranasal RSP Live® (CV), and (iv) a control group of non-vaccinated calves (CONT). The calves\' serological response post-IN vaccination, clinical health scores, rectal temperatures, and weights were measured. Data were analyzed in SAS using mixed models and logistic regression. The CV calves had an average daily weight gain (ADG) of 0.74 (±0.02) kg, which was similar to CONT (0.77 ± 0.02 kg). Despite no significant differences in the antibody levels between study groups 3 weeks post-IN vaccination, following the administration of subsequent parenteral injections in the form of Bovilis Bovipast RSP®(antigens; inactivated BRSV, inactivated PI3-V, inactivated Mannheimia haemolytica) and Bovilis IBR Marker Live®, the antibody levels of the BRSV and PI3-V increased in both the CV and RPO study groups. Concurrent vaccination resulted in no increase in fever and no difference in health scores when compared to CONT.
摘要：
尽管肺炎仍然是断奶前小牛死亡和发病的主要原因，关于同时施用鼻内肺炎病毒疫苗的效果相对知之甚少，特别是在母源抗体含量高的小牛中。这项研究的目的是使用40只乳牛和乳牛雌性和雄性小牛（27只雌性和13只雄性）的队列，以确定在3周龄（22±4.85天）同时施用两种市售鼻内（IN）病毒疫苗的血清学反应：牛呼吸道合胞病毒（BRSV），牛疱疹病毒1（BoHV-1），和副流感病毒-3-病毒（PI3-V）。研究组如下：(i)BovilisIBRMarkerLiveonly®(IO)，（ii）Bovilis鼻内RSPLive®（RPO），（iii）同时接种BovilisIBR标记Live®和Bovilis鼻内RSPLive®（CV），和(iv)对照组的未接种小牛(CONT)。接种疫苗后小牛的血清学反应，临床健康评分,直肠温度,并测量体重。使用混合模型和逻辑回归在SAS中分析数据。CV小牛的平均日增重（ADG）为0.74（±0.02）kg，与CONT相似(0.77±0.02kg)。尽管接种疫苗3周后研究组之间的抗体水平没有显着差异，随后以BovilisBovipastRSP®（抗原；灭活的BRSV，灭活的PI3-V，灭活的溶血曼海姆氏菌)和BovilisIBRMarkerLive®，CV和RPO研究组的BRSV和PI3-V抗体水平均升高.与CONT相比，同时接种疫苗没有导致发烧增加，健康评分也没有差异。
