PDF(Pubmed)
Abstract：
Multidisciplinary team from three universities based in the \"Centro\" Region of Portugal developed diverse approaches as parts of a project dedicated to enhancing and expanding Predictive, Preventive, and Personalized Medicine (3PM) in the Region. In a sense, outcomes acted as a proof-of-concept, in that they demonstrated the feasibility, but also the relevance of the approaches. The accomplishments comprise defining a new regional strategy for implementing 3PM within the Region, training of human resources in genomic sequencing, and generating good practices handbooks dedicated to diagnostic testing via next-generation sequencing, to legal and ethical concerns, and to knowledge transfer and entrepreneurship, aimed at increasing literacy on 3PM approaches. Further approaches also included support for entrepreneurship development and start-ups, and diverse and relevant initiatives aimed at increasing literacy relevant to 3PM. Efforts to enhance literacy encompassed citizens across the board, from patients and high school students to health professionals and health students. This focus on empowerment through literacy involved a variety of initiatives, including the creation of an illustrated book on genomics and the production of two theater plays centered on genetics. Additionally, authors stressed that genomic tools are relevant, but they are not the only resources 3PM is based on. Thus, they defend that other initiatives intended to enable citizens to take 3PM should include multi-omics and, having in mind the socio-economic burden of chronic diseases, suboptimal health status approaches in the 3PM framework should also be considered, in order to anticipate medical intervention in the subclinical phase.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s13167-024-00353-9.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s13167-024-00353-9.
摘要：
来自葡萄牙“Centro”地区三所大学的多学科团队开发了多种方法，作为致力于增强和扩展预测性项目的一部分，预防性,以及该地区的个性化医疗（3PM）。在某种意义上,结果作为一个概念证明，因为他们证明了可行性，还有方法的相关性。这些成就包括为在该区域内实施3PM制定新的区域战略，基因组测序人力资源培训，并通过下一代测序生成专门用于诊断测试的良好实践手册，法律和道德问题，知识转移和创业，旨在提高下午3点的识字率。进一步的方法还包括支持创业发展和初创企业，以及旨在提高与下午3点相关的识字率的多样化和相关举措。提高识字率的努力涵盖了所有公民，从病人和高中生到健康专业人员和健康学生。这种通过扫盲赋权的重点涉及各种举措，包括创作一本关于基因组学的插图书，以及制作两部以遗传学为中心的戏剧。此外,作者强调基因组工具是相关的，但它们并不是3PM所基于的唯一资源。因此，他们辩称，其他旨在使公民能够采取下午3点的举措应该包括多元组学，考虑到慢性病的社会经济负担，还应考虑3PM框架中的次优健康状况方法，为了预测亚临床阶段的医疗干预。
■在线版本包含补充材料，可在10.1007/s13167-024-00353-9获得。
■在线版本包含补充材料，可在10.1007/s13167-024-00353-9获得。
