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Abstract：
OBJECTIVE: To analyze the predictive value of coagulation function, alpha-fetoprotein (AFP) and placental growth factor (PIGF) for postpartum hemorrhage in patients with perilous placenta previa (PPP).
METHODS: The clinical data of 104 PPP patients were retrospectively analyzed. The patients were divided into a hemorrhage group (n=68) and a non-hemorrhage group (n=36). A total of 55 healthy pregnant women were recruited as controls. The coagulation function, AFP and PIGF were compared between the three groups. Multivariate logistic regression was performed to determine independent risk factors for hemorrhage.
RESULTS: PT, TT, APTT, FIB and AFP were significantly higher while PIGF was lower in the PPP group than the control group (all P<0.05). Placental adhesion (OR 3.924, 95% CI 1.389-11.083, P=0.01), anterior placenta (OR 4.583, 95% CI 1.589-13.22, P=0.005), AFP (OR 0.208, 95% CI 0.068-0.635, P=0.006) and PIGF (OR 3.963, 95% CI 1.385-11.34, P=0.01) were independent risk factors for hemorrhage.
CONCLUSIONS: Coagulation function, AFP and PIGF could predict postpartum hemorrhage in PPP patients.
METHODS: The clinical data of 104 PPP patients were retrospectively analyzed. The patients were divided into a hemorrhage group (n=68) and a non-hemorrhage group (n=36). A total of 55 healthy pregnant women were recruited as controls. The coagulation function, AFP and PIGF were compared between the three groups. Multivariate logistic regression was performed to determine independent risk factors for hemorrhage.
RESULTS: PT, TT, APTT, FIB and AFP were significantly higher while PIGF was lower in the PPP group than the control group (all P<0.05). Placental adhesion (OR 3.924, 95% CI 1.389-11.083, P=0.01), anterior placenta (OR 4.583, 95% CI 1.589-13.22, P=0.005), AFP (OR 0.208, 95% CI 0.068-0.635, P=0.006) and PIGF (OR 3.963, 95% CI 1.385-11.34, P=0.01) were independent risk factors for hemorrhage.
CONCLUSIONS: Coagulation function, AFP and PIGF could predict postpartum hemorrhage in PPP patients.
摘要：
目的：分析凝血功能的预测价值，甲胎蛋白（AFP）和胎盘生长因子（PIGF）对凶险性前置胎盘（PPP）患者产后出血的影响。
方法：对104例PPP患者的临床资料进行回顾性分析。将患者分为出血组（n=68）和非出血组（n=36）。共招募55名健康孕妇作为对照。凝血功能，比较三组的AFP和PIGF。采用多因素logistic回归分析确定出血的独立危险因素。
结果：PT，TT,APTT,PPP组FIB和AFP显著高于对照组,而PIGF显著低于对照组(均P<0.05)。胎盘粘连(OR3.924,95%CI1.389-11.083,P=0.01),前胎盘(OR4.583,95%CI1.589-13.22,P=0.005),AFP（OR0.208，95％CI0.068-0.635，P=0.006）和PIGF（OR3.963，95％CI1.385-11.34，P=0.01）是出血的独立危险因素。
结论：凝血功能，AFP和PIGF可预测PPP患者产后出血。
方法：对104例PPP患者的临床资料进行回顾性分析。将患者分为出血组（n=68）和非出血组（n=36）。共招募55名健康孕妇作为对照。凝血功能，比较三组的AFP和PIGF。采用多因素logistic回归分析确定出血的独立危险因素。
结果：PT，TT,APTT,PPP组FIB和AFP显著高于对照组,而PIGF显著低于对照组(均P<0.05)。胎盘粘连(OR3.924,95%CI1.389-11.083,P=0.01),前胎盘(OR4.583,95%CI1.589-13.22,P=0.005),AFP（OR0.208，95％CI0.068-0.635，P=0.006）和PIGF（OR3.963，95％CI1.385-11.34，P=0.01）是出血的独立危险因素。
结论：凝血功能，AFP和PIGF可预测PPP患者产后出血。
