PDF(Pubmed)
Abstract：
OBJECTIVE: To explore the clinical significance of detecting mycoplasma pneumoniae (MP)-DNA, C-reactive protein (CRP), interleukin-6 (IL-6), IL-8, and IL-10 in children with mycoplasma pneumoniae pneumonia (MPP).
METHODS: The data from 106 children who received treatment or underwent health examination in the Children\'s Medical Center of Anhui Medical University from January 2021 to October 2022 were collected and analyzed retrospectively. The observation group (OG) consisted of 64 children with MPP, while the control group (CG) consisted of 42 healthy children. The levels of IL-6, IL-8, IL-10, CRP, and MP-DNA were compared between the two groups. The diagnostic value of MP-DNA in patients with MPP and its correlation with the levels of IL-6, IL-8, IL-10 and CRP were analyzed.
RESULTS: The level of MP-DNA in the OG was notably higher than that in the CG (P<0.05). Additionally, the levels of IL-6, IL-8, IL-10, and CRP in the OG were significantly higher than those in the CG (P<0.05). MP-DNA was positively correlated with the levels of IL-6, IL-8, IL-10, and CRP (P<0.05). The area under the curve of MP-DNA in diagnosing MPP was 0.979, with a specificity of 92.19% and a sensitivity of 97.62%.
CONCLUSIONS: Indicators such as MP-DAN, IL-6, IL-8 are crucial in the development and progression of MPP, playing an important role in diagnosing and treating patients with MPP.
METHODS: The data from 106 children who received treatment or underwent health examination in the Children\'s Medical Center of Anhui Medical University from January 2021 to October 2022 were collected and analyzed retrospectively. The observation group (OG) consisted of 64 children with MPP, while the control group (CG) consisted of 42 healthy children. The levels of IL-6, IL-8, IL-10, CRP, and MP-DNA were compared between the two groups. The diagnostic value of MP-DNA in patients with MPP and its correlation with the levels of IL-6, IL-8, IL-10 and CRP were analyzed.
RESULTS: The level of MP-DNA in the OG was notably higher than that in the CG (P<0.05). Additionally, the levels of IL-6, IL-8, IL-10, and CRP in the OG were significantly higher than those in the CG (P<0.05). MP-DNA was positively correlated with the levels of IL-6, IL-8, IL-10, and CRP (P<0.05). The area under the curve of MP-DNA in diagnosing MPP was 0.979, with a specificity of 92.19% and a sensitivity of 97.62%.
CONCLUSIONS: Indicators such as MP-DAN, IL-6, IL-8 are crucial in the development and progression of MPP, playing an important role in diagnosing and treating patients with MPP.
摘要：
目的:探讨肺炎支原体(MP)-DNA检测的临床意义,C反应蛋白(CRP),白细胞介素-6（IL-6），肺炎支原体肺炎（MPP）患儿的IL-8和IL-10。
方法：收集2021年1月至2022年10月在安徽医科大学儿童医学中心接受治疗或体检的106例儿童的资料进行回顾性分析。观察组(OG)为64例MPP患儿,对照组(CG)由42名健康儿童组成。IL-6、IL-8、IL-10、CRP、比较两组患者的MP-DNA。分析MP-DNA对MPP患者的诊断价值及其与IL-6、IL-8、IL-10、CRP水平的相关性。
结果：OG中MP-DNA水平明显高于CG（P<0.05）。此外,OG组IL-6、IL-8、IL-10和CRP水平明显高于CG组(P<0.05)。MP-DNA与IL-6、IL-8、IL-10、CRP水平呈正相关(P<0.05)。MP-DNA诊断MPP的曲线下面积为0.979,特异性为92.19%,敏感性为97.62%。
结论：指标，如MP-DAN，IL-6、IL-8在MPP的发生发展中起着至关重要的作用,在MPP患者的诊断和治疗中发挥着重要作用。
方法：收集2021年1月至2022年10月在安徽医科大学儿童医学中心接受治疗或体检的106例儿童的资料进行回顾性分析。观察组(OG)为64例MPP患儿,对照组(CG)由42名健康儿童组成。IL-6、IL-8、IL-10、CRP、比较两组患者的MP-DNA。分析MP-DNA对MPP患者的诊断价值及其与IL-6、IL-8、IL-10、CRP水平的相关性。
结果：OG中MP-DNA水平明显高于CG（P<0.05）。此外,OG组IL-6、IL-8、IL-10和CRP水平明显高于CG组(P<0.05)。MP-DNA与IL-6、IL-8、IL-10、CRP水平呈正相关(P<0.05)。MP-DNA诊断MPP的曲线下面积为0.979,特异性为92.19%,敏感性为97.62%。
结论：指标，如MP-DAN，IL-6、IL-8在MPP的发生发展中起着至关重要的作用,在MPP患者的诊断和治疗中发挥着重要作用。
