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Abstract：
Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition of the nasal and paranasal tissues, characterized by the presence of bilateral nasal polyps. While etiology and pathogenetic mechanisms are heterogeneous and complex, in most patients, disease is mediated predominantly through type 2 inflammatory processes. Clinical management is challenging, and a multidisciplinary approach is preferred. Principal treatment approaches are the use of local/systemic corticosteroids and sinonasal surgery, although outcomes can be unsatisfactory. Recent availability of biological therapies targeting underlying inflammatory processes can offer effective treatment options in uncontrolled disease. Specialist guidelines greatly assist clinical decision-making, although as these are chiefly written from a global/international perspective, they may not wholly accommodate disease patterns and clinical practice at a regional level. An expert panel of specialists from Latin America was convened to develop regional guidance on the management of CRSwNP through a consensus approach. The present article presents the chief observations and recommendations which can provide guidance for clinicians in the Latin American region.
摘要：
慢性鼻窦炎伴鼻息肉（CRSwNP）是鼻和鼻旁组织的炎症，以双侧鼻息肉为特征。虽然病因和发病机制是异质和复杂的，在大多数患者中，疾病主要通过2型炎症过程介导。临床管理具有挑战性，多学科方法是首选。主要治疗方法是使用局部/全身皮质类固醇和鼻窦手术，尽管结果可能不令人满意。针对潜在炎症过程的生物疗法的最新可用性可以为不受控制的疾病提供有效的治疗选择。专家指南极大地帮助临床决策，尽管这些主要是从全球/国际角度编写的，它们可能不完全适应区域一级的疾病模式和临床实践。召集了一个由拉丁美洲专家组成的专家小组，以协商一致的方式制定关于CRSwNP管理的区域指南。本文介绍了主要的观察和建议，可以为拉丁美洲地区的临床医生提供指导。
