Abstract：
Antigen presentation to CD8+ T cells by MHC class I molecules is essential for host defense against viral infections. Various mechanisms have evolved in multiple viruses to escape immune surveillance and defense to support viral proliferation in host cells. Through in vitro SARS-CoV-2 infection studies and analysis of COVID-19 patient samples, we found that SARS-CoV-2 suppresses the induction of the MHC class I pathway by inhibiting the expression and function of NLRC5, a major transcriptional regulator of MHC class I genes. In this review, we discuss the molecular mechanisms for suppression of the MHC class I pathway and clinical implications for COVID-19.
摘要：
MHCI类分子向CD8+T细胞的抗原呈递对于宿主防御病毒感染是必需的。多种机制已经在多种病毒中进化以逃避免疫监视和防御以支持宿主细胞中的病毒增殖。通过体外SARS-CoV-2感染研究和COVID-19患者样本分析，我们发现SARS-CoV-2通过抑制MHCI类基因的主要转录调节因子NLRC5的表达和功能来抑制MHCI类途径的诱导。在这次审查中,我们讨论了抑制MHCI类通路的分子机制和对COVID-19的临床意义。
