PDF(Pubmed)
Abstract：
The association between the gut mycobiome and its potential influence on host metabolism in the Thai Cohort was assessed. Two distinct predominant enterotypes, Saccharomyces (Sa) and Aspergillus/Penicillium (Ap/Pe) showed differences in gut mycobiota diversity and composition. Notably, the Sa enterotype exhibited lower evenness and richness, likely due to the prevalence of Saccharomyces, while both enterotypes displayed unique metabolic behaviors related to nutrient metabolism and body composition. Fiber consumption was positively correlated with adverse body composition and fasting glucose levels in individuals with the Sa enterotype, whereas in the Ap/Pe enterotype it was positively correlated with fat and protein intake. The metabolic functional analysis revealed the Sa enterotype associated with carbohydrate metabolism, while the Ap/Pe enterotype involved in lipid metabolism. Very interestingly, the genes involved in the pentose and glucuronate interconversion pathway, such as polygalacturonase and L-arabinose-isomerase, were enriched in the Sa enterotype signifying a metabolic capacity for complex carbohydrate degradation and utilization of less common sugars as energy sources. These findings highlight the interplay between gut mycobiome composition, dietary habits, and metabolic outcomes within the Thai cohort studies.
摘要：
评估了泰国队列中肠道真菌生物群组及其对宿主代谢的潜在影响之间的关联。两种不同的优势肠型，酵母菌属（Sa）和曲霉/青霉属（Ap/Pe）在肠道菌群多样性和组成上显示出差异。值得注意的是,Sa肠型表现出较低的均匀度和丰富度，可能是由于酵母菌的流行,而两种肠型均表现出与营养代谢和身体成分相关的独特代谢行为。纤维消耗与Sa肠型个体的不良身体成分和空腹血糖水平呈正相关，而在Ap/Pe肠型中，它与脂肪和蛋白质摄入量呈正相关。代谢功能分析揭示了与碳水化合物代谢相关的Sa肠型，而Ap/Pe肠型参与脂质代谢。非常有趣的是，参与戊糖和葡糖醛酸互变途径的基因，如聚半乳糖醛酸酶和L-阿拉伯糖异构酶，富含Sa肠型，这表明具有代谢能力，可以降解复杂的碳水化合物，并利用较不常见的糖作为能源。这些发现强调了肠道真菌组成之间的相互作用，饮食习惯，泰国队列研究中的代谢结果。
