PDF(Pubmed)
Abstract：
BACKGROUND: Patients with neuromuscular disease often have a weak and ineffective cough due to respiratory muscle weakness. One treatment option is mechanical insufflation-exsufflation (MI-E), also known as cough assist, which is known to increase cough strength. However, some patients have a laryngeal response to MI-E, which can make the treatment ineffective. Currently, the only method for assessing this is via nasal endoscopy while using MI-E. Some MI-E devices have onboard secure data (SD) cards, which allow the visualisation of waveforms. We hypothesise that the waveforms can be used to identify laryngeal responses to the MI-E.
METHODS: Participants will complete baseline assessments of spirometry, peak cough flow and sniff nasal inspiratory pressure. A nasal endoscope will be used to visualise the larynx during simultaneous MI-E via a mask with a drilled hole. MI-E will be delivered by an experienced physiotherapist. Four cycles of MI-E at a range of prescriptions will be delivered. MI-E waveforms will be downloaded into Care Orchestrator Essence software (Philips, Murraysville). Data will be collected prospectively and reviewed in a descriptive context, providing trends and potential rationales describing the waveforms in comparison to the nasal endoscope videos.
BACKGROUND: This protocol has been reviewed by the East of England-Cambridge Central Research Ethics Committee, who have granted a favourable ethical opinion. The study opened to recruitment in January 2022 and aims to publish trial results in June 2024.
BACKGROUND: NCT05189600.
METHODS: Participants will complete baseline assessments of spirometry, peak cough flow and sniff nasal inspiratory pressure. A nasal endoscope will be used to visualise the larynx during simultaneous MI-E via a mask with a drilled hole. MI-E will be delivered by an experienced physiotherapist. Four cycles of MI-E at a range of prescriptions will be delivered. MI-E waveforms will be downloaded into Care Orchestrator Essence software (Philips, Murraysville). Data will be collected prospectively and reviewed in a descriptive context, providing trends and potential rationales describing the waveforms in comparison to the nasal endoscope videos.
BACKGROUND: This protocol has been reviewed by the East of England-Cambridge Central Research Ethics Committee, who have granted a favourable ethical opinion. The study opened to recruitment in January 2022 and aims to publish trial results in June 2024.
BACKGROUND: NCT05189600.
摘要：
背景：患有神经肌肉疾病的患者通常由于呼吸肌无力而咳嗽无力且无效。一种治疗选择是机械吹气-排气（MI-E），也称为咳嗽辅助，已知会增加咳嗽强度。然而,一些患者对MI-E有喉部反应，这会使治疗无效。目前,唯一的评估方法是通过鼻内窥镜检查，同时使用MI-E。某些MI-E设备具有板载安全数据(SD)卡，这允许波形的可视化。我们假设波形可用于识别喉部对MI-E的反应。
方法：参与者将完成肺活量测定的基线评估，峰值咳嗽流量和嗅探鼻吸气压力。鼻内窥镜将用于通过带有钻孔的面罩在同时MI-E期间可视化喉。MI-E将由经验丰富的物理治疗师交付。将提供一系列处方的四个周期的MI-E。MI-E波形将下载到CareOrchestratorEssence软件(飞利浦,Murraysville）。将前瞻性地收集数据，并在描述性背景下进行审查，与鼻内窥镜视频相比，提供描述波形的趋势和潜在理由。
背景：该协议已由英格兰东部-剑桥中央研究伦理委员会审查，给予了有利的伦理意见。该研究于2022年1月开始招募，旨在于2024年6月公布试验结果。
背景：NCT05189600。
方法：参与者将完成肺活量测定的基线评估，峰值咳嗽流量和嗅探鼻吸气压力。鼻内窥镜将用于通过带有钻孔的面罩在同时MI-E期间可视化喉。MI-E将由经验丰富的物理治疗师交付。将提供一系列处方的四个周期的MI-E。MI-E波形将下载到CareOrchestratorEssence软件(飞利浦,Murraysville）。将前瞻性地收集数据，并在描述性背景下进行审查，与鼻内窥镜视频相比，提供描述波形的趋势和潜在理由。
背景：该协议已由英格兰东部-剑桥中央研究伦理委员会审查，给予了有利的伦理意见。该研究于2022年1月开始招募，旨在于2024年6月公布试验结果。
背景：NCT05189600。
