Abstract：
OBJECTIVE: To explore the association between chronic prostatitis (CP) and the subsequent development of benign prostatic hyperplasia (BPH).
METHODS: Data analyzed were medical claims of Taiwan\'s National Health Insurance program. From 2010 to 2017, 3571 patients ≧20 years with CP diagnosed by certified urologists were enrolled. Patients with past BPH diagnosis and diagnosis of prostate cancer, inguinal hernia, interstitial cystitis, and urethritis in the past and within one year after the first CP diagnosis were excluded. Age-matched controls were randomly selected from all non-CP individuals of the same exclusion criteria in the study period with a CP/non-CP ratio of 1:4. The follow-up was made from the first CP diagnosis to death or the end of 2018. The endpoint was the newly diagnosed BPH. Cox proportional hazard regression model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) of BPH in association with CP.
RESULTS: Over a maximum of 8 years of follow-up, 287 (8.03%) and 258 (0.43%) BPH events were noted for the CP and non-CP group, respectively, representing a covariate adjusted HR (aHR) of 4.30 (95% CI, 3.61-5.13). Younger patients tended to suffer from higher aHRs, especially those aged 20-39 years (aHR: 11.45, 95% CI, 5.12-25.64).
CONCLUSIONS: The Taiwan national health database indicated that CP patients had a significantly higher risk of developing BPH later than non-CP patients. Interestingly, the younger the CP is diagnosed (under 40), the greater the risk.
METHODS: Data analyzed were medical claims of Taiwan\'s National Health Insurance program. From 2010 to 2017, 3571 patients ≧20 years with CP diagnosed by certified urologists were enrolled. Patients with past BPH diagnosis and diagnosis of prostate cancer, inguinal hernia, interstitial cystitis, and urethritis in the past and within one year after the first CP diagnosis were excluded. Age-matched controls were randomly selected from all non-CP individuals of the same exclusion criteria in the study period with a CP/non-CP ratio of 1:4. The follow-up was made from the first CP diagnosis to death or the end of 2018. The endpoint was the newly diagnosed BPH. Cox proportional hazard regression model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) of BPH in association with CP.
RESULTS: Over a maximum of 8 years of follow-up, 287 (8.03%) and 258 (0.43%) BPH events were noted for the CP and non-CP group, respectively, representing a covariate adjusted HR (aHR) of 4.30 (95% CI, 3.61-5.13). Younger patients tended to suffer from higher aHRs, especially those aged 20-39 years (aHR: 11.45, 95% CI, 5.12-25.64).
CONCLUSIONS: The Taiwan national health database indicated that CP patients had a significantly higher risk of developing BPH later than non-CP patients. Interestingly, the younger the CP is diagnosed (under 40), the greater the risk.
摘要：
目的：探讨慢性前列腺炎（CP）与良性前列腺增生（BPH）的关系。
方法：分析的数据是台湾国民健康保险计划的医疗索赔。从2010年到2017年，纳入了3571例经认证的泌尿科医师诊断的≥20岁的CP患者。既往BPH诊断和前列腺癌诊断的患者，腹股沟疝,间质性膀胱炎,排除过去和首次CP诊断后一年内的尿道炎。在研究期间从具有相同排除标准的所有非CP个体中随机选择年龄匹配的对照,CP/非CP比率为1:4。从第一次CP诊断到死亡或2018年底进行随访。终点是新诊断的BPH。Cox比例风险回归模型用于估计BPH与CP相关的风险比（HR）和95％置信区间（CI）。
结果：经过最长8年的随访，CP和非CP组发生287例（8.03%）和258例（0.43%）BPH事件，分别,代表协变量调整后的HR(aHR)为4.30(95%CI，3.61-5.13)。年轻患者往往患有较高的aHR，尤其是20-39岁的人群（aHR：11.45，95%CI，5.12-25.64）。
结论：台湾国家健康数据库表明，CP患者比非CP患者晚期发展为BPH的风险明显更高。有趣的是,诊断出CP越年轻（40岁以下），风险越大。
方法：分析的数据是台湾国民健康保险计划的医疗索赔。从2010年到2017年，纳入了3571例经认证的泌尿科医师诊断的≥20岁的CP患者。既往BPH诊断和前列腺癌诊断的患者，腹股沟疝,间质性膀胱炎,排除过去和首次CP诊断后一年内的尿道炎。在研究期间从具有相同排除标准的所有非CP个体中随机选择年龄匹配的对照,CP/非CP比率为1:4。从第一次CP诊断到死亡或2018年底进行随访。终点是新诊断的BPH。Cox比例风险回归模型用于估计BPH与CP相关的风险比（HR）和95％置信区间（CI）。
结果：经过最长8年的随访，CP和非CP组发生287例（8.03%）和258例（0.43%）BPH事件，分别,代表协变量调整后的HR(aHR)为4.30(95%CI，3.61-5.13)。年轻患者往往患有较高的aHR，尤其是20-39岁的人群（aHR：11.45，95%CI，5.12-25.64）。
结论：台湾国家健康数据库表明，CP患者比非CP患者晚期发展为BPH的风险明显更高。有趣的是,诊断出CP越年轻（40岁以下），风险越大。
