Abstract：
The wound-healing process in diabetic foot is affected by pro and anti-inflammatory markers, and any disruption in the inflammatory reaction interferes with tissue homeostasis, leading to chronic non-wound healing.
This study aimed to determine the diagnostic value and effect of CRP, IL-6, TNF, and HbA1c on initiation the and progression of diabetic foot ulcers.
ELISA was used to quantify IL-6, TNF, CRP, and HbA1c in 205 patients with diabetes, and 105 were diabetic foot free. The prevalence and progression of diabetic foot were also evaluated. The area under the curve (AUC) was calculated using the receiver operating characteristic (ROC) curve to analyze the predictive values. Forward stepwise logistic regression analysis was used to compute the odds ratio (OR) and the corresponding 95% confidence intervals (CIs).
CRP, IL-6, and FBS were found to be significant predictors of diabetic foot (OR=1.717, 95% CI=1.250-2.358, P=0.001; OR=1.434, 95% CI=1.142-1.802, P=0.002; and OR=1.040, 95% CI=1.002-1.080, P=0.037), respectively. The AUCs for CRP, IL-6, and HbA1c in predicting diabetic foot were 0.839, 0.728, and 0.834, respectively, demonstrating a good predictive value for each diagnostic marker.
The current study demonstrated that IL-6, CRP, and HbA1c may be useful biomarkers to indicate diabetic foot progression. Furthermore, our findings showed a substantial relationship between CRP and HbA1c in individuals with diabetic foot conditions.
This study aimed to determine the diagnostic value and effect of CRP, IL-6, TNF, and HbA1c on initiation the and progression of diabetic foot ulcers.
ELISA was used to quantify IL-6, TNF, CRP, and HbA1c in 205 patients with diabetes, and 105 were diabetic foot free. The prevalence and progression of diabetic foot were also evaluated. The area under the curve (AUC) was calculated using the receiver operating characteristic (ROC) curve to analyze the predictive values. Forward stepwise logistic regression analysis was used to compute the odds ratio (OR) and the corresponding 95% confidence intervals (CIs).
CRP, IL-6, and FBS were found to be significant predictors of diabetic foot (OR=1.717, 95% CI=1.250-2.358, P=0.001; OR=1.434, 95% CI=1.142-1.802, P=0.002; and OR=1.040, 95% CI=1.002-1.080, P=0.037), respectively. The AUCs for CRP, IL-6, and HbA1c in predicting diabetic foot were 0.839, 0.728, and 0.834, respectively, demonstrating a good predictive value for each diagnostic marker.
The current study demonstrated that IL-6, CRP, and HbA1c may be useful biomarkers to indicate diabetic foot progression. Furthermore, our findings showed a substantial relationship between CRP and HbA1c in individuals with diabetic foot conditions.
摘要：
背景：糖尿病足的伤口愈合过程受到促炎和抗炎标志物的影响，炎症反应的任何破坏都会干扰组织的稳态，导致慢性非伤口愈合。
目的：本研究旨在确定CRP的诊断价值和作用，IL-6,TNF,和HbA1c对糖尿病足溃疡的开始和进展。
方法：ELISA用于定量IL-6，TNF，CRP,205名糖尿病患者的HbA1c，105人没有糖尿病足。还评估了糖尿病足的患病率和进展。使用接受者工作特征(ROC)曲线计算曲线下面积(AUC)以分析预测值。使用正向逐步逻辑回归分析来计算比值比（OR）和相应的95％置信区间（CI）。
结果：CRP，发现IL-6和FBS是糖尿病足的重要预测因子（OR=1.717，95％CI=1.250-2.358，P=0.001；OR=1.434，95％CI=1.142-1.802，P=0.002；OR=1.040，95％CI=1.002-1.080，P=0.037）。分别。CRP的AUC，预测糖尿病足的IL-6和HbA1c分别为0.839、0.728和0.834,对每个诊断标记物都有良好的预测价值。
结论：目前的研究表明，IL-6，CRP，HbA1c可能是指示糖尿病足进展的有用生物标志物。此外，我们的研究结果显示,糖尿病足患者的CRP和HbA1c之间存在显著关系.
目的：本研究旨在确定CRP的诊断价值和作用，IL-6,TNF,和HbA1c对糖尿病足溃疡的开始和进展。
方法：ELISA用于定量IL-6，TNF，CRP,205名糖尿病患者的HbA1c，105人没有糖尿病足。还评估了糖尿病足的患病率和进展。使用接受者工作特征(ROC)曲线计算曲线下面积(AUC)以分析预测值。使用正向逐步逻辑回归分析来计算比值比（OR）和相应的95％置信区间（CI）。
结果：CRP，发现IL-6和FBS是糖尿病足的重要预测因子（OR=1.717，95％CI=1.250-2.358，P=0.001；OR=1.434，95％CI=1.142-1.802，P=0.002；OR=1.040，95％CI=1.002-1.080，P=0.037）。分别。CRP的AUC，预测糖尿病足的IL-6和HbA1c分别为0.839、0.728和0.834,对每个诊断标记物都有良好的预测价值。
结论：目前的研究表明，IL-6，CRP，HbA1c可能是指示糖尿病足进展的有用生物标志物。此外，我们的研究结果显示,糖尿病足患者的CRP和HbA1c之间存在显著关系.
