Abstract：
The gut microbiota, a complex and dynamic microbial ecosystem, plays a crucial role in regulating the intestinal barrier. Polysaccharide foraging is specifically dedicated to establishing and maintaining microbial communities, contributing to the shaping of the intestinal ecosystem and ultimately enhancing the integrity of the intestinal barrier. The utilization and regulation of individual polysaccharides often rely on distinct gut-colonizing bacteria. The products of their metabolism not only benefit the formation of the ecosystem but also facilitate cross-feeding partnerships. In this review, we elucidate the mechanisms by which specific bacteria degrade polysaccharides, and how polysaccharide metabolism shapes the microbial ecosystem through cross-feeding. Furthermore, we explore how selectively promoting microbial ecosystems and their metabolites contributes to improvements in the integrity of the intestinal barrier.
摘要：
肠道微生物群，一个复杂而动态的微生物生态系统，在调节肠道屏障中起着至关重要的作用。多糖觅食专门致力于建立和维持微生物群落，有助于肠道生态系统的塑造，并最终增强肠道屏障的完整性。单个多糖的利用和调节通常依赖于不同的肠道定殖细菌。它们的代谢产物不仅有利于生态系统的形成，而且有利于交叉饲养伙伴关系。在这次审查中,我们阐明了特定细菌降解多糖的机制，以及多糖代谢如何通过交叉饲喂塑造微生物生态系统。此外，我们探讨了选择性地促进微生物生态系统及其代谢产物如何有助于改善肠道屏障的完整性。
