Abstract：
BACKGROUND: Congenital malformations of the central nervous system (CNS) are morphological abnormalities of the brain and spinal cord that occur during fetal development. They constitute the second most common congenital disability, after congenital cardiac defects. Many risk factors have been identified; however, these studies included various types of congenital abnormality. Furthermore, there is a lack of information on risk factors for congenital CNS malformation, and notably in the Zinder region of Niger.
OBJECTIVE: This study aimed to identify the risk factors associated with congenital CNS malformations in the Zinder region.
METHODS: In a case-control design, patients with congenital CNS malformation were enrolled between June 2022 and April 2023 in the Department of Neurosurgery of the National Hospital of Zinder.
RESULTS: Family history of malformation (aOR:3.31, 95% CI:1.25-8.78) and consanguine marriage (aOR:2.28, 95% CI:1.23-4.20) were significantly associated with congenital CNS malformation. In contrast, folic acid supplementation (aOR:0.34, 95% CI:0.13, 0.89), multiparity (aOR:0.34, 95% CI:0.13, 0.89), and grand multiparity (aOR, 0.47; 95% CI:0.23, 0.97) had a protective effect.
CONCLUSIONS: Risk factors such as family malformation history and consanguine marriage increased the risk of developing congenital malformations of the central nervous system. In contrast, folic acid supplementation in the index period and multiparity had a significant protective effect.
OBJECTIVE: This study aimed to identify the risk factors associated with congenital CNS malformations in the Zinder region.
METHODS: In a case-control design, patients with congenital CNS malformation were enrolled between June 2022 and April 2023 in the Department of Neurosurgery of the National Hospital of Zinder.
RESULTS: Family history of malformation (aOR:3.31, 95% CI:1.25-8.78) and consanguine marriage (aOR:2.28, 95% CI:1.23-4.20) were significantly associated with congenital CNS malformation. In contrast, folic acid supplementation (aOR:0.34, 95% CI:0.13, 0.89), multiparity (aOR:0.34, 95% CI:0.13, 0.89), and grand multiparity (aOR, 0.47; 95% CI:0.23, 0.97) had a protective effect.
CONCLUSIONS: Risk factors such as family malformation history and consanguine marriage increased the risk of developing congenital malformations of the central nervous system. In contrast, folic acid supplementation in the index period and multiparity had a significant protective effect.
摘要：
背景：中枢神经系统（CNS）的先天性畸形是在胎儿发育过程中发生的脑和脊髓的形态异常。它们构成了第二常见的先天性残疾，先天性心脏缺陷后。已经确定了许多风险因素；然而，这些研究包括各种类型的先天性异常。此外，缺乏有关先天性中枢神经系统畸形危险因素的信息，尤其是在尼日尔的Zinder地区。
目的：本研究旨在确定与Zinder地区先天性CNS畸形相关的危险因素。
方法：在病例对照设计中，2022年6月至2023年4月,Zinder国家医院神经外科纳入了先天性CNS畸形患者.
结果：畸形家族史（aOR：3.31，95％CI：1.25-8.78）和血缘关系（aOR：2.28，95％CI：1.23-4.20）与先天性中枢神经系统畸形明显相关。相比之下,补充叶酸（OR：0.34，95%CI：0.13，0.89），多重奇偶校验(AOR：0.34，95%CI：0.13，0.89)，和大多重奇偶校验(aOR，0.47；95%CI：0.23，0.97）有保护作用。
结论：危险因素如家族畸形史和血缘关系婚姻增加了发生中枢神经系统先天性畸形的风险。相比之下,在指数期和多胎期补充叶酸具有显著的保护作用。
目的：本研究旨在确定与Zinder地区先天性CNS畸形相关的危险因素。
方法：在病例对照设计中，2022年6月至2023年4月,Zinder国家医院神经外科纳入了先天性CNS畸形患者.
结果：畸形家族史（aOR：3.31，95％CI：1.25-8.78）和血缘关系（aOR：2.28，95％CI：1.23-4.20）与先天性中枢神经系统畸形明显相关。相比之下,补充叶酸（OR：0.34，95%CI：0.13，0.89），多重奇偶校验(AOR：0.34，95%CI：0.13，0.89)，和大多重奇偶校验(aOR，0.47；95%CI：0.23，0.97）有保护作用。
结论：危险因素如家族畸形史和血缘关系婚姻增加了发生中枢神经系统先天性畸形的风险。相比之下,在指数期和多胎期补充叶酸具有显著的保护作用。
