OBJECTIVE: This study aimed to identify the risk factors associated with congenital CNS malformations in the Zinder region.
METHODS: In a case-control design, patients with congenital CNS malformation were enrolled between June 2022 and April 2023 in the Department of Neurosurgery of the National Hospital of Zinder.
RESULTS: Family history of malformation (aOR:3.31, 95% CI:1.25-8.78) and consanguine marriage (aOR:2.28, 95% CI:1.23-4.20) were significantly associated with congenital CNS malformation. In contrast, folic acid supplementation (aOR:0.34, 95% CI:0.13, 0.89), multiparity (aOR:0.34, 95% CI:0.13, 0.89), and grand multiparity (aOR, 0.47; 95% CI:0.23, 0.97) had a protective effect.
CONCLUSIONS: Risk factors such as family malformation history and consanguine marriage increased the risk of developing congenital malformations of the central nervous system. In contrast, folic acid supplementation in the index period and multiparity had a significant protective effect.
目的:本研究旨在确定与Zinder地区先天性CNS畸形相关的危险因素。
方法:在病例对照设计中,2022年6月至2023年4月,Zinder国家医院神经外科纳入了先天性CNS畸形患者.
结果:畸形家族史(aOR:3.31,95%CI:1.25-8.78)和血缘关系(aOR:2.28,95%CI:1.23-4.20)与先天性中枢神经系统畸形明显相关。相比之下,补充叶酸(OR:0.34,95%CI:0.13,0.89),多重奇偶校验(AOR:0.34,95%CI:0.13,0.89),和大多重奇偶校验(aOR,0.47;95%CI:0.23,0.97)有保护作用。
结论:危险因素如家族畸形史和血缘关系婚姻增加了发生中枢神经系统先天性畸形的风险。相比之下,在指数期和多胎期补充叶酸具有显著的保护作用。