PDF(Pubmed)
Abstract：
OBJECTIVE: Familial hypercholesterolemia (FH) is one of the most common inherited diseases characterized by elevated LDL-cholesterol levels, leading to early-onset atherosclerosis. While the association between FH and coronary and carotid artery disease is well-established, its association with peripheral artery disease (PAD) is less robust. This systematic review aims at exploring existing evidence on PAD prevalence and incidence in FH individuals.
METHODS: A comprehensive search was conducted on MEDLINE and Embase databases, for studies published between January 2013 and December 2023, evaluating prevalence and incidence of PAD in FH patients. Literature reviews, case reports, responses to editors and non-English language articles were excluded.
RESULTS: The initial research provided 53 results. After article screening, 28 articles were fully reviewed and 24 were finally included in the analysis. Among these, 19 reported PAD prevalence, while 5 PAD incidence over a mean follow-up time of 8.7 years. PAD prevalence and incidence ranged from 0.3 to 60% and from 0.5 to 4.2% respectively, probably reflecting the heterogeneity in PAD definition criteria.
CONCLUSIONS: This systematic review sheds light on the limited number of studies on PAD in FH patients. Particularly, considering the potential positive effects of newly available lipid-lowering strategies on PAD outcomes, addressing this research gap is pivotal for a more comprehensive understanding of peripheral vascular manifestations in FH patients and for optimal management of this population.
METHODS: A comprehensive search was conducted on MEDLINE and Embase databases, for studies published between January 2013 and December 2023, evaluating prevalence and incidence of PAD in FH patients. Literature reviews, case reports, responses to editors and non-English language articles were excluded.
RESULTS: The initial research provided 53 results. After article screening, 28 articles were fully reviewed and 24 were finally included in the analysis. Among these, 19 reported PAD prevalence, while 5 PAD incidence over a mean follow-up time of 8.7 years. PAD prevalence and incidence ranged from 0.3 to 60% and from 0.5 to 4.2% respectively, probably reflecting the heterogeneity in PAD definition criteria.
CONCLUSIONS: This systematic review sheds light on the limited number of studies on PAD in FH patients. Particularly, considering the potential positive effects of newly available lipid-lowering strategies on PAD outcomes, addressing this research gap is pivotal for a more comprehensive understanding of peripheral vascular manifestations in FH patients and for optimal management of this population.
摘要：
目的：家族性高胆固醇血症（FH）是以LDL-胆固醇水平升高为特征的最常见的遗传性疾病之一，导致早发性动脉粥样硬化。虽然FH与冠状动脉和颈动脉疾病之间的关联已得到证实，其与外周动脉疾病(PAD)的相关性较低.本系统综述旨在探索FH个体PAD患病率和发病率的现有证据。
方法：对MEDLINE和Embase数据库进行了全面检索，对于2013年1月至2023年12月发表的研究，评估了FH患者中PAD的患病率和发病率。文献综述,病例报告,对编辑和非英语文章的回复被排除在外。
结果：初步研究提供了53个结果。文章筛选后,对28篇文章进行了全面回顾，最终将24篇纳入分析。其中,19例报告PAD患病率，而在8.7年的平均随访时间内，PAD发病率为5。PAD患病率和发病率分别为0.3％至60％和0.5％至4.2％，可能反映了PAD定义标准的异质性。
结论：本系统综述揭示了在FH患者中关于PAD的研究数量有限。特别是,考虑到新可用的降脂策略对PAD结局的潜在积极影响，解决这一研究差距对于更全面地了解FH患者的外周血管表现以及对该人群的最佳管理至关重要.
方法：对MEDLINE和Embase数据库进行了全面检索，对于2013年1月至2023年12月发表的研究，评估了FH患者中PAD的患病率和发病率。文献综述,病例报告,对编辑和非英语文章的回复被排除在外。
结果：初步研究提供了53个结果。文章筛选后,对28篇文章进行了全面回顾，最终将24篇纳入分析。其中,19例报告PAD患病率，而在8.7年的平均随访时间内，PAD发病率为5。PAD患病率和发病率分别为0.3％至60％和0.5％至4.2％，可能反映了PAD定义标准的异质性。
结论：本系统综述揭示了在FH患者中关于PAD的研究数量有限。特别是,考虑到新可用的降脂策略对PAD结局的潜在积极影响，解决这一研究差距对于更全面地了解FH患者的外周血管表现以及对该人群的最佳管理至关重要.
