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Abstract：
Background Surgical procedures such as excision of a growth or lesion lead to soft tissue or oral mucosal defects. These defects require a proper surgical dressing to promote better wound healing and to avoid infection and scarring. A collagen membrane is one of the most commonly used surgical dressings because of its ease of adaptability to defects and its inherent ability to promote epithelialization and inhibition of pain through the indirect mechanism of preventing infection of the surgical site. Collagen also serves as a reservoir of regenerative factors. The regenerative potential increases as porosity decreases. The novel bovine-derived collagen membrane used in this current study has an average porosity of 20 microns which increases the availability of regenerative factors. Objective The aim of this study was to compare the effectiveness between a novel matrix-modified bovine collagen membrane (SurgiColl) and a conventional bovine collagen membrane for promoting wound healing for oral mucosal or soft tissue defects. Materials and methods This clinical trial was conducted in the Department of Oral and Maxillofacial Surgery, Saveetha Dental College and Hospital. The sample size of the study was 20, divided into two groups: novel bovine collagen (Surgicoll-Mesh) (Group 1) and conventional bovine collagen (Group 2) with 10 participants in each group. The randomization process was adopted. The parameters assessed were epithelialization, granulation, and wound contraction at the end of two weeks. All the parameters were assessed using a standardized visual assessment scale. Statistical analysis was done using IBM SPSS Statistics for Windows, Version 23.0 (Released 2015; IBM Corp., Armonk, New York, United States), and an independent sample t-test was done at 95% confidence interval. A p-value of less than 0.05 was considered statistically significant. Results The difference in epithelialization between the two groups was statistically significant with a p-value of 0.015 (<0.05). The difference in granulation tissue formation between the two groups was statistically significant with a p-value of 0.015 (<0.05). The difference in wound contraction at the end of two weeks between the two groups was also statistically significant with a p-value of 0.005 (<0.05). Group 1 showed superior results compared to Group 2 for all the outcomes assessed. Conclusion The novel bovine-derived collagen membrane (SurgiColl-Mesh) was superior in its properties of wound healing for oral mucosal or soft tissue defects than the conventional bovine collagen membrane.
摘要：
背景技术诸如切除生长或损伤的外科手术导致软组织或口腔粘膜缺损。这些缺陷需要适当的外科敷料以促进更好的伤口愈合并避免感染和瘢痕形成。胶原蛋白膜是最常用的外科敷料之一，因为它易于适应缺陷，并且具有通过预防手术部位感染的间接机制促进上皮化和抑制疼痛的固有能力。胶原蛋白还充当再生因子的储库。再生潜力随着孔隙率的降低而增加。本研究中使用的新型牛衍生的胶原膜具有20微米的平均孔隙率，这增加了再生因子的可用性。目的本研究的目的是比较新型基质修饰的牛胶原膜（SurgiColl）和常规牛胶原膜促进口腔粘膜或软组织缺损伤口愈合的有效性。材料与方法本临床试验在口腔颌面外科进行,Saveetha牙科学院和医院。研究的样本量为20，分为两组：新型牛胶原蛋白（Surgicoll-Mesh）（第1组）和常规牛胶原蛋白（第2组），每组10名参与者。采用随机化过程。评估的参数是上皮化，造粒,两周后伤口收缩。使用标准化视觉评估量表评估所有参数。统计分析是使用IBMSPSSStatisticsforWindows进行的，版本23.0（2015年发布；IBMCorp.,Armonk,纽约,美国),以95%置信区间进行独立样本t检验。小于0.05的P值被认为是统计学上显著的。结果两组上皮形成差异有统计学意义,p值为0.015(<0.05)。两组间肉芽组织形成差异有统计学意义,p值为0.015(<0.05)。两组在两周结束时伤口收缩的差异也具有统计学意义，p值为0.005（<0.05）。对于所有评估的结果，第1组显示出优于第2组的结果。结论新型牛源性胶原膜(SurgiColl-Mesh)对口腔黏膜或软组织缺损的创面愈合性能优于常规牛胶原膜。
