PDF(Pubmed)
Abstract：
A 51-year-old man with a history of cisplatin treatment for a right testicular tumor underwent microvascular decompression for hemifacial spasm. At an early stage in the surgical procedure, the intraoperative auditory brainstem response (ABR) was diminished despite a relatively minimally invasive approach, resulting in irreversible hearing loss. Cisplatin is known to cause dose-dependent hearing impairment primarily affecting the cochlea, but it can also induce neurotoxicity. In the present case, prior cisplatin administration may have caused fragility of the cochlear nerve as well. Patients with a history of ototoxic and neurotoxic drugs such as cisplatin require more careful manipulation and thorough intraoperative auditory monitoring during neurosurgical procedures that may affect hearing, such as those for hemifacial spasms.
摘要：
一名患有顺铂治疗右睾丸肿瘤病史的51岁男子接受了面肌痉挛的微血管减压术。在外科手术的早期阶段,术中听性脑干反应（ABR）减弱，尽管采用了相对微创的方法，导致不可逆的听力损失。已知顺铂会导致剂量依赖性听力损害，主要影响耳蜗，但它也会引起神经毒性。在目前的情况下,以前服用顺铂也可能导致耳蜗神经脆弱。有耳毒性和神经毒性药物如顺铂病史的患者在神经外科手术期间需要更仔细的操作和彻底的术中听觉监测，这可能会影响听力。比如半面痉挛。
