PDF(Pubmed)
Abstract：
Microorganisms can takeover critical metabolic pathways in host cells to fuel their replication. This interaction provides an opportunity to target host metabolic pathways, in addition to the pathogen-specific ones, in the development of antimicrobials. Host-directed therapy (HDT) is an emerging strategy of anti-infective therapy, which targets host cell metabolism utilized by facultative and obligate intracellular pathogens for entry, replication, egress or persistence of infected host cells. This review provides an overview of the host lipid metabolism and links it to the challenges in the development of HDTs for viral and bacterial infections, where pathogens are using important for the host lipid enzymes, or producing their own analogous of lecithin-cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL) thus interfering with the human host\'s lipid metabolism.
摘要：
微生物可以接管宿主细胞中的关键代谢途径以促进其复制。这种相互作用提供了靶向宿主代谢途径的机会，除了病原体特异性的，在抗菌药物的开发中。宿主导向治疗(HDT)是一种新兴的抗感染治疗策略,目标是兼性和专性细胞内病原体进入的宿主细胞代谢，复制,感染的宿主细胞的出口或持久性。这篇综述提供了宿主脂质代谢的概述，并将其与开发用于病毒和细菌感染的HDT的挑战联系起来。病原体对宿主脂质酶很重要，或产生自身类似的卵磷脂-胆固醇酰基转移酶（LCAT）和脂蛋白脂肪酶（LPL），从而干扰人类宿主的脂质代谢。
