PDF(Pubmed)
Abstract：
In this review, we will explore the intricate roles of cytokines and vascular endothelial growth factors in autoimmune diseases (ADs), with a particular focus on rheumatoid arthritis (RA) and multiple sclerosis (MS). AD is characterized by self-destructive immune responses due to auto-reactive T lymphocytes and Abs. Among various types of ADs, RA and MS possess inflammation as a central role but in different sites of the patients. Other common aspects among these two ADs are their chronicity and relapsing-remitting symptoms requiring continuous management. First factor inducing these ADs are cytokines, such as IL-6, TNF-α, and IL-17, which play significant roles in the pathogenesis by contributing to inflammation, immune cell activation, and tissue damage. Secondly, vascular endothelial growth factors, including VEGF and angiopoietins, are crucial in promoting angiogenesis and inflammation in these two ADs. Finally, placental growth factor (PlGF), an emerging factor with bi-directional roles in angiogenesis and T cell differentiation, as we introduce as an \"angio-lymphokine\" is another key factor in ADs. Thus, while angiogenesis recruits more inflammatory cells into the peripheral sites, cytokines secreted by effector cells play critical roles in the pathogenesis of ADs. Various therapeutic interventions targeting these soluble molecules have shown promise in managing autoimmune pathogenic conditions. However, delicate interplay between cytokines, angiogenic factors, and PlGF has more to be studied when considering their complementary role in actual pathogenic conditions. Understanding the complex interactions among these factors provides valuable insights for the development of innovative therapies for RA and MS, offering hope for improved patient outcomes.
摘要：
在这次审查中,我们将探讨细胞因子和血管内皮生长因子在自身免疫性疾病（ADs）中的复杂作用，特别关注类风湿性关节炎（RA）和多发性硬化症（MS）。AD的特征在于由自身反应性T淋巴细胞和Ab引起的自我破坏性免疫应答。在各种类型的广告中，RA和MS具有炎症作为中心作用,但在患者的不同部位。这两种AD中的其他常见方面是它们的慢性和需要持续管理的复发缓解症状。诱导这些AD的第一个因素是细胞因子，如IL-6，TNF-α，和IL-17，通过促进炎症在发病机理中起重要作用，免疫细胞激活，和组织损伤。其次,血管内皮生长因子，包括VEGF和血管生成素,在这两种AD中促进血管生成和炎症至关重要。最后,胎盘生长因子(PlGF),在血管生成和T细胞分化中具有双向作用的新兴因子，正如我们引入的“血管淋巴因子”是广告中的另一个关键因素。因此，而血管生成会招募更多的炎症细胞进入外周部位，效应细胞分泌的细胞因子在ADs的发病机制中起关键作用。靶向这些可溶性分子的各种治疗干预已显示出在管理自身免疫致病状况方面的希望。然而,细胞因子之间微妙的相互作用，血管生成因子，在考虑PlGF在实际致病条件下的互补作用时，还需要对它们进行更多的研究。了解这些因素之间复杂的相互作用为开发RA和MS的创新疗法提供了有价值的见解。为改善患者预后提供希望。
