PDF(Pubmed)
Abstract：
We report the first case of severe pain and inflammation reduction by application of purified amniotic fluid on active lesions of a patient with pyoderma gangrenosum. We describe the impact of every third-day skin applications of a sterile fraction (4ml) from human purified amniotic fluid (ViX001) obtained from thoroughly screened volunteers at the time of planned c-section at the term of normal pregnancies. The product ViX001 was generated through a proprietary process and kept in frozen one or two milliliters cryovials (protein content was ~1mg/ml) and thawed just prior to applications. Pain improvement was recorded after each application, and inflammation suppression was confirmed by serial pictures of the lesions. While our findings need to be reproduced with a larger cohort of patients, preferably at an earlier stage of the disease, it is instructive that ViX001 reduced severe pain and inflammation for a patient with advanced pyoderma gangrenosum. Pyoderma gangrenosum is a dreadful skin condition consisting of noninfectious neutrophilic dermatosis that progresses to necrotic ulcers with a characteristic purple edge and extremely painful raw subdermal tissue exposure.
摘要：
我们报告了第一例通过在坏疽性脓皮病患者的活动性病变上应用纯化的羊水来减轻严重疼痛和炎症的情况。我们描述了在正常妊娠期间计划剖腹产时，从经过彻底筛查的志愿者获得的人纯化羊水（ViX001）中每三天皮肤应用无菌部分（4ml）的影响。产品ViX001是通过专有方法生成的，并保存在冷冻的一毫升或两毫升冷冻小瓶中（蛋白质含量为〜1mg/ml），并在应用前解冻。每次应用后记录疼痛改善情况，和炎症抑制被证实的连续图片的病变。虽然我们的发现需要在更大的患者队列中重现，最好是在疾病的早期阶段，ViX001减轻了晚期坏疽性脓皮病患者的严重疼痛和炎症，具有指导意义。坏疽性脓皮病是一种可怕的皮肤病，由非感染性嗜中性皮肤病组成，可发展为坏死性溃疡，具有特征性的紫色边缘和极其痛苦的原始皮下组织暴露。
