PDF(Pubmed)
Abstract：
Tizanidine, an α2-adrenergic receptor agonist commonly prescribed as a muscle relaxant, has been associated with limited cases of acute intoxication or withdrawal. Here, we present a case of tizanidine withdrawal in a woman in her 40s who presented with an unusual combination of systemic and neurological symptoms. These included hallucinations, decorticate posture, limb and eyelid tremors, along with hypertension, tachycardia and tachypnoea. The diagnosis of tizanidine withdrawal was established by a comprehensive assessment of the patient\'s medical history and the systematic exclusion of other potential diseases. Our approach to managing the withdrawal symptoms was to initiate symptomatic treatment with a combination of a beta-blocker and a calcium channel blocker. Remarkably, this intervention successfully resolved both vital signs and neurological manifestations by the following day. In conclusion, tizanidine withdrawal is associated with a distinct and diagnostically significant neurological syndrome characterised by hallucinations, decorticate posture, tremors and hypersympathetic vital signs.
摘要：
替扎尼定,通常作为肌肉松弛剂的α2-肾上腺素能受体激动剂，与有限的急性中毒或戒断病例有关。这里,我们介绍了一例40多岁的女性替扎尼定戒断的病例，她出现了不寻常的全身和神经系统症状。这些包括幻觉，装饰姿势，肢体和眼睑震颤，伴随着高血压,心动过速和呼吸急促.通过全面评估患者的病史并系统排除其他潜在疾病，可以确定替扎尼定戒断的诊断。我们管理戒断症状的方法是使用β受体阻滞剂和钙通道阻滞剂的组合开始对症治疗。值得注意的是,该干预措施于次日成功解决了生命体征和神经系统表现.总之,替扎尼定戒断与以幻觉为特征的独特且具有诊断意义的神经系统综合征有关，装饰姿势，震颤和高交感神经生命体征。
