METHODS: We employed information from the National Health and Nutrition Examination Survey (NHANES) 1999-2010 for cross-sectional analysis. Weighted logistic regression was employed to explore the linear relationship between BRI and albuminuria, with subgroup analyses performed for more detailed insights. Weighted linear regression analysis was employed to explore the relationship between BRI and the urine albumin-creatinine ratio (UACR). Additionally, we applied smooth curve fitting to investigate their non-linear relationship and conducted threshold effect analysis to identify any turning point.
RESULTS: In this study of 15,487 participants aged 8-19 years, multivariate logistic regression analysis revealed a significant negative correlation between BRI and albuminuria (OR = 0.616, 95%CI: 0.526-0.722). The relationship between BRI and UACR, as shown by multivariate linear regression analysis, was significantly inversely correlated (β: -5.424, 95%CI: -7.416 to -3.433). Furthermore, smooth curve fitting and threshold effect analysis showed a non-linear relationship between BRI and albuminuria, with a BRI inflection point identified at 2.906.
CONCLUSIONS: These findings of our study suggest a significant nonlinear negative association between BRI and the presence of albuminuria among children and teenagers, and maintaining an appropriate BRI may decrease the occurrence of albuminuria in this population.
方法:我们采用1999-2010年国家健康和营养调查(NHANES)的信息进行横断面分析。采用加权logistic回归分析BRI与蛋白尿的线性关系,进行亚组分析以获得更详细的见解。采用加权线性回归分析BRI与尿白蛋白-肌酐比值(UACR)的关系。此外,我们应用平滑曲线拟合来研究它们的非线性关系,并进行阈值效应分析来确定任何转折点.
结果:在这项8-19岁的15,487名参与者的研究中,多因素logistic回归分析显示BRI与蛋白尿呈显著负相关(OR=0.616,95CI:0.526~0.722)。BRI与UACR的关系,如多元线性回归分析所示,呈显著负相关(β:-5.424,95CI:-7.416至-3.433)。此外,平滑曲线拟合和阈值效应分析显示,BRI与蛋白尿呈非线性关系,BRI拐点确定为2.906。
结论:我们的研究结果表明,在儿童和青少年中,BRI与蛋白尿之间存在显著的非线性负相关,维持适当的BRI可能会减少该人群中蛋白尿的发生。