Abstract：
BACKGROUND: In the medical field, it is increasingly common to observe the use of nanotubes, for example, in the administration of drugs. However, nanotubes raise concerns for male fertility due to potential effects on hormone levels and sperm quality observed in animal studies. In addition, animal exposure to multi-walled carbon nanotube models found alterations in hormone levels, sperm motility, and sperm count. Limited evidence in humans suggests no adverse effects, but further research is needed. This study aimed to perform a systematic review to assess the in vitro effects of nanotubes on semen and fertility in humans.
METHODS: We included all published in vitro studies about semen or sperm or male fertility and nanotubes in humans. A search was conducted in LILACS, PubMed, and SCOPUS as of May 2023. The risk of bias was assessed using the QUIN tool.
RESULTS: Four studies using nanotubes on human sperm were included, nanotubes exposure appears not to affect sperm viability; however, some alterations to motility, velocity and production of reactive oxygen species were reported. Limited evidence is provided because of the small quantity of publications.
CONCLUSIONS: Nanotubes appear to have no adverse effects on human sperm.
METHODS: We included all published in vitro studies about semen or sperm or male fertility and nanotubes in humans. A search was conducted in LILACS, PubMed, and SCOPUS as of May 2023. The risk of bias was assessed using the QUIN tool.
RESULTS: Four studies using nanotubes on human sperm were included, nanotubes exposure appears not to affect sperm viability; however, some alterations to motility, velocity and production of reactive oxygen species were reported. Limited evidence is provided because of the small quantity of publications.
CONCLUSIONS: Nanotubes appear to have no adverse effects on human sperm.
摘要：
背景：在医学领域，观察纳米管的使用越来越普遍，例如,在药物管理方面。然而,由于在动物研究中观察到的对激素水平和精子质量的潜在影响，纳米管引起了对男性生育能力的关注。此外,动物暴露于多壁碳纳米管模型发现激素水平的变化，精子运动性,和精子计数。人类的有限证据表明没有副作用，但还需要进一步的研究。本研究旨在进行系统评价，以评估纳米管对人类精液和生育能力的体外影响。
方法：我们包括了所有已发表的关于精液或精子或男性生育力和人体纳米管的体外研究。在LILACS进行了搜索，PubMed,和截至2023年5月的SCOPUS。使用QUIN工具评估偏倚风险。
结果：包括四项使用纳米管对人类精子的研究，纳米管暴露似乎不会影响精子活力；然而，对运动性的一些改变，报告了活性氧的速度和产量。由于出版物数量少，提供的证据有限。
结论：纳米管似乎对人精子没有不良影响。
方法：我们包括了所有已发表的关于精液或精子或男性生育力和人体纳米管的体外研究。在LILACS进行了搜索，PubMed,和截至2023年5月的SCOPUS。使用QUIN工具评估偏倚风险。
结果：包括四项使用纳米管对人类精子的研究，纳米管暴露似乎不会影响精子活力；然而，对运动性的一些改变，报告了活性氧的速度和产量。由于出版物数量少，提供的证据有限。
结论：纳米管似乎对人精子没有不良影响。
