关键词: biomarker cognitive function estradiol gerontology national survey

来  源:   DOI:10.3389/fnagi.2024.1356791   PDF(Pubmed)

Abstract:
UNASSIGNED: Estradiol is a sex steroid hormone, which has been implicated in the pathogenesis of Alzheimer\'s disease and cognitive impairment. This cross-sectional study aimed to examine the relationship between serum estradiol levels and cognitive performance in older American women.
UNASSIGNED: Data were obtained from the National Health and Nutrition Examination Survey 2013-2014. A total of 731 women aged ≥60 years who met the inclusion criteria were included in this study. Serum estradiol levels were measured using the isotope dilution liquid chromatography tandem mass spectrometry (ID-LC-MS/MS) method developed by the Centers for Disease Control and Prevention for routine analysis. All measured serum levels were further divided into three parts: T1, <3.68 pg./mL; T2, 3.68-7.49 pg./mL; T3, >7.49 pg./mL, and analyzed. Participants\' cognitive abilities were tested using the Vocabulary Learning Subtest (CERAD), Animal Fluency Test (AFS), and digital symbol substitution test (DSST). Scores for each test were calculated based on the sample mean and standard deviation (SD). To examine the relationship between serum estradiol level tertiles and cognitive scores, multiple linear regression models were developed, controlling for race/ethnicity, education level, hypertension, diabetes, and insomnia.
UNASSIGNED: The mean age of the participants was 69.57 ± 6.68 years. The non-Hispanic whites were 78.95%, and those who had completed at least some college-level education were 60.62%. The mean BMI of the participants was 29.30 ± 6.79, and 10.85% had a history of smoking. Further, 73.41% did not have a history of alcohol consumption, and 63.03% had hypertension (63.03%). In addition, 81.81 and 88.3% did not have a history of diabetes mellitus and did not have sleep disorders, respectively. The mean serum estradiol level was 8.48 ± 0.77 pg./mL. Multivariate linear regression of the reference group consisting of participants in tertiles of serum estradiol levels revealed that one unit increase in serum estradiol levels increased DSST scores by 0.61 (0.87, 6.34) in the T3 group. However, no significant correlation was found in the CERAD and AFS tests.
UNASSIGNED: Participants with higher estradiol levels had higher DSST scores and better processing speed, sustained attention, and working memory, suggesting that serum estradiol may serve as a biomarker for cognitive decline in older women.
摘要:
雌二醇是一种性类固醇激素,这与阿尔茨海默病和认知障碍的发病机制有关。这项横断面研究旨在研究血清雌二醇水平与美国老年女性认知能力之间的关系。
数据来自2013-2014年全国健康和营养检查调查。共有731名年龄≥60岁且符合纳入标准的女性纳入本研究。使用疾病控制和预防中心开发的同位素稀释液相色谱串联质谱(ID-LC-MS/MS)方法测量血清雌二醇水平,以进行常规分析。所有测量的血清水平进一步分为三个部分:T1,<3.68pg。/mL;T2,3.68-7.49pg。/mL;T3,>7.49pg。/mL,并分析。参与者的认知能力使用词汇学习子测验(CERAD)进行测试,动物流畅度测试(AFS),和数字符号替换测试(DSST)。基于样品平均值和标准偏差(SD)计算每个测试的得分。为了检查血清雌二醇水平三位数与认知评分之间的关系,建立了多元线性回归模型,控制种族/民族,教育水平,高血压,糖尿病,和失眠。
参与者的平均年龄为69.57±6.68岁。非西班牙裔白人占78.95%,完成至少一些大学教育的人占60.62%。参与者的平均BMI为29.30±6.79,10.85%有吸烟史。Further,73.41%没有饮酒史,高血压占63.03%(63.03%)。此外,81.81和88.3%没有糖尿病病史,也没有睡眠障碍,分别。平均血清雌二醇水平为8.48±0.77pg。/mL。由血清雌二醇水平三位数参与者组成的参考组的多元线性回归显示,T3组血清雌二醇水平增加一个单位,使DSST评分增加0.61(0.87,6.34)。然而,在CERAD和AFS测试中没有发现显著的相关性.
雌二醇水平较高的参与者的DSST分数更高,处理速度更好,持续关注,和工作记忆,提示血清雌二醇可作为老年女性认知功能减退的生物标志物。
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