Abstract：
Calcitonin gene-related peptide (CGRP) and histamine plasma concentrations increase during migraine attacks. Both mediators are potent vasodilators, and they have been shown to reciprocally contribute to the release of each other in the trigeminovascular system, possibly driving migraine development. A high-histamine-content diet triggers migraine in patients who have histamine degradation deficiency owing to diaminooxidase (DAO) gene mutations. Therefore, studying functional links between exogenous histamine and CGRP seems promising for the understanding of diet-induced migraine generation. Notably, there is a lack of knowledge about the interplay of the enteric nervous system and the spinal/trigeminal somatosensory system with regard to CGRP and histamine. Based on background evidence, we propose that a functional interconnection between exogenous histamine and CGRP contributes to migraine development.
摘要：
降钙素基因相关肽（CGRP）和组胺血浆浓度在偏头痛发作期间增加。两种介质都是有效的血管扩张剂，它们被证明在三叉神经血管系统中相互促进彼此的释放，可能会导致偏头痛的发展。由于二氨基氧化酶（DAO）基因突变，高组胺含量的饮食会引发组胺降解缺乏症患者的偏头痛。因此,研究外源性组胺和CGRP之间的功能联系对于理解饮食诱导的偏头痛的产生似乎很有希望。值得注意的是,关于CGRP和组胺，缺乏有关肠神经系统和脊髓/三叉神经体感系统相互作用的知识。根据背景证据,我们认为外源性组胺和CGRP之间的功能相互联系有助于偏头痛的发展。外源性组胺可能在功能上与降钙素基因相关肽（CGRP）的产生有关，发现可能的肠道与三叉神经的联系，这可能是食物组胺引起的偏头痛发作的关键。
