PDF(Pubmed)
Abstract：
Emerging therapies in bioelectronic medicine highlight the need for deeper understanding of electrode material performance in the context of tissue stimulation. Electrochemical properties are characterized on the benchtop, facilitating standardization across experiments. On-nerve electrochemistry differs from benchtop characterization and the relationship between electrochemical performance and nerve activation thresholds are not commonly established. This relationship is important in understanding differences between electrical stimulation requirements and electrode performance. We report functional electrochemistry as a follow-up to benchtop testing, describing a novel experimental approach for evaluating on-nerve electrochemical performance in the context of nerve activation. An ex-vivo rat sciatic nerve preparation was developed to quantify activation thresholds of fiber subtypes and electrode material charge injection limits for platinum iridium, iridium oxide, titanium nitride and PEDOT. Finally, we address experimental complexities arising in these studies, and demonstrate statistical solutions that support rigorous material performance comparisons for decision making in neural interface development.
摘要：
生物电子医学中的新兴疗法突出了在组织刺激的背景下对电极材料性能的更深入理解的需要。电化学性能的特点是在工作台上，促进跨实验的标准化。神经上电化学不同于台式表征,并且通常不建立电化学性能与神经激活阈值之间的关系。这种关系对于理解电刺激要求和电极性能之间的差异是重要的。我们报告了功能电化学作为台式测试的后续行动，描述了一种在神经激活的背景下评估神经电化学性能的新实验方法。开发了离体大鼠坐骨神经制剂，以量化铂铱的纤维亚型和电极材料电荷注射极限的激活阈值，氧化铱,氮化钛和PEDOT。最后,我们解决了这些研究中出现的实验复杂性，并演示统计解决方案，支持严格的材料性能比较，以便在神经接口开发中进行决策。
