PDF(Pubmed)
Abstract：
This review provides a comprehensive exploration of the intricate relationship between statins and stroke prevention within the broader context of cardiovascular health. Delving into the mechanisms of statins, we elucidate their multifaceted contributions, ranging from cholesterol reduction to pleiotropic effects on the vascular system. Through a meticulous analysis of clinical trials, observational studies, and mechanistic investigations, we underscore the pivotal role of statins as integral components in the arsenal against strokes and associated cardiovascular events. The implications extend beyond statins as standalone interventions, emphasizing the potential for synergistic integration into broader stroke prevention strategies. Tailoring interventions to individual patient profiles and understanding the interplay with lifestyle modifications and other pharmacological approaches present opportunities for optimizing efficacy. Recommendations for future research advocate for continued exploration into the long-term effects of statin therapy, novel intervention combinations, and refined predictive models for personalized risk assessment. On a practical level, enhancing patient education, fostering interdisciplinary collaboration, and addressing barriers to medication adherence emerge as crucial aspects for real-world impact. In navigating this evolving landscape, the insights derived from this review contribute to informed decision-making and advancements in preventive cardiovascular medicine.
摘要：
这篇综述在更广泛的心血管健康背景下，全面探索了他汀类药物与卒中预防之间的复杂关系。深入研究他汀类药物的作用机制，我们阐明了他们多方面的贡献，从降低胆固醇到对血管系统的多效性作用。通过对临床试验的细致分析,观察性研究，和机械调查，我们强调了他汀类药物作为预防卒中和相关心血管事件的重要组成部分的关键作用.其影响超出了他汀类药物作为独立干预措施的范围，强调协同整合到更广泛的卒中预防策略的潜力。针对个体患者概况定制干预措施并理解与生活方式改变和其他药理学方法的相互作用为优化功效提供了机会。对未来研究的建议提倡继续探索他汀类药物治疗的长期效果，新颖的干预组合，和完善的预测模型，用于个性化风险评估。在实际层面上，加强患者教育，促进跨学科合作，解决药物依从性的障碍成为现实世界影响的关键方面。在导航这个不断变化的景观时，从这篇综述中得出的见解有助于预防性心血管医学的知情决策和进步.
