PDF(Pubmed)
Abstract：
The objective of this study is to evaluate the effectiveness and safety of ozone therapy (OT) in the treatment of knee osteoarthritis (KOA), which is the most common form of the disease. We analysed systematic reviews (SRs) of randomised controlled trials (RCTs) using the \"A MeaSurement Tool to Assess systematic Reviews\" (AMSTAR2) instrument to evaluate their quality. We developed a narrative synthesis report with eight SRs (15 RCTs/3,685 patients) to summarise the findings. The AMSTAR2 analysis indicated that all reviews had critically low confidence ratings. Statistically significant effects in pain reduction using OT compared to placebo groups were reported in three SRs. OT was shown to be comparable to other therapies in one SR and not superior in the other five. Six SRs highlighted the need for additional RCTs with improved methodological quality to confirm the efficacy of OT for KOA. SRs found fewer consistent effects for improving joint function. Regarding safety, seven SRs reported a low prevalence of minor adverse events linked with OT. Finally, this umbrella review highlights the beneficial effects and safety of OT in the treatment of KOA, particularly in pain control. The low methodological quality of RCTs and SRs limits the possibility of drawing conclusions on the effectiveness of the procedure in comparison to other therapies. Ensure adequate compliance with guidelines such as Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and AMSTAR2 has the ability to improve the quality of SRs in this area.
摘要：
这项研究的目的是评估臭氧疗法（OT）在治疗膝骨关节炎（KOA）的有效性和安全性，这是该疾病最常见的形式。我们使用“评估系统评价的计量工具”（AMSTAR2）工具分析了随机对照试验（RCT）的系统评价（SRs），以评估其质量。我们开发了一份包含8个SR（15个RCT/3,685名患者）的叙述性综合报告，以总结研究结果。AMSTAR2分析表明，所有评论的置信度都非常低。在三个SR中报告了与安慰剂组相比，使用OT减轻疼痛的统计学显着效果。在一个SR中，OT与其他疗法相当，而在其他五个SR中并不优越。六个SR强调了需要具有改进的方法学质量的额外随机对照试验，以确认OT对KOA的疗效。SRs发现改善关节功能的一致性效果较少。关于安全,7个SRs报告与OT相关的轻微不良事件发生率较低.最后,这篇综述强调了OT治疗KOA的有益效果和安全性，尤其是在疼痛控制方面。与其他疗法相比，RCT和SRs的方法学质量低限制了对该方法的有效性得出结论的可能性。确保充分遵守诸如系统审查和荟萃分析的首选报告项目（PRISMA）和AMSTAR2之类的指南，以提高该领域的SR质量。
