PDF(Pubmed)
Abstract：
Regeneration of injured tendons and ligaments (T/L) is a worldwide need. In this study electrospun hierarchical scaffolds made of a poly-L (lactic) acid/collagen blend were developed reproducing all the multiscale levels of aggregation of these tissues. Scanning electron microscopy, microCT and tensile mechanical tests were carried out, including a multiscale digital volume correlation analysis to measure the full-field strain distribution of electrospun structures. The principal strains (εp1 and εp3) described the pattern of strains caused by the nanofibers rearrangement, while the deviatoric strains (εD) revealed the related internal sliding of nanofibers and bundles. The results of this study confirmed the biomimicry of such electrospun hierarchical scaffolds, paving the way to further tissue engineering and clinical applications.
摘要：
损伤的肌腱和韧带(T/L)的再生是全世界的需要。在这项研究中，开发了由聚L（乳酸）酸/胶原蛋白混合物制成的电纺分层支架，从而再现了这些组织的所有多尺度聚集水平。扫描电子显微镜，进行了显微CT和拉伸机械测试，包括多尺度数字体积相关分析来测量电纺结构的全场应变分布。主要应变（εp1和εp3）描述了纳米纤维重排引起的应变模式，而偏差应变（εD）揭示了纳米纤维和束的相关内部滑动。这项研究的结果证实了这种电纺分层支架的仿生，为进一步组织工程和临床应用铺平了道路。
