PDF(Pubmed)
Abstract：
Acute genital ulcers can affect females of all ages. In children, they often appear as an emergency and remain a diagnostic challenge for pediatricians, gynecologists and dermatologists. Prompt diagnosis and identification of disease- related factors help to implement appropriate treatment. Firstly, it is crucial to properly compile the past medical history of the patient. Past infectious, autoimmune, malignant or traumatic conditions, as well as vaccinations may contribute to the occurrence of acute genital ulcers. Moreover, new infectious agents, such as severe acute respiratory syndrome coronavirus 2 and vaccinations against Coronavirus disease of 2019, may play a significant role in the development of atypical clinical symptoms. Here we present a case of a 12-year-old girl with acute genital ulcers. Additional symptoms accompanying the ulcer included: abdominal pain, nausea, vomiting, dysuria, vulvar pain and fever. Blood test showed leukocytosis, especially neutrophilia and monocytosis and increased levels of c-reactive protein and procalcitonin. Serological tests for the most common infections were negative. Moreover, the patient had a history of autoimmune diseases. She had periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome, and IgA vasculitis, also known as Henoch-Schönlein purpura in her past medical history. Additionally, she was vaccinated against SARS-CoV-2 shortly before the lesions appeared.
摘要：
急性生殖器溃疡可影响所有年龄段的女性。在儿童中，它们经常出现在紧急情况下，仍然是儿科医生的诊断挑战，妇科医生和皮肤科医生。及时诊断和识别疾病相关因素有助于实施适当的治疗。首先,正确收集患者的既往病史至关重要。过去的传染性，自身免疫，恶性或创伤性疾病，以及疫苗接种可能有助于急性生殖器溃疡的发生。此外，新的传染因子,例如严重急性呼吸综合征冠状病毒2和2019年冠状病毒疾病的疫苗接种，可能在非典型临床症状的发展中起重要作用。在这里，我们介绍了一个患有急性生殖器溃疡的12岁女孩的病例。伴随溃疡的其他症状包括：腹痛，恶心,呕吐,排尿困难,外阴疼痛和发烧。血液检查显示白细胞增多,尤其是中性粒细胞增多和单核细胞增多以及C反应蛋白和降钙素原水平升高。最常见感染的血清学检查均为阴性。此外，患者有自身免疫性疾病史。她有周期性发烧,口疮性口炎，咽炎,和甲状腺炎综合征,IgA血管炎,在她过去的病史中也被称为过敏性紫癜。此外,在病变出现前不久，她接种了SARS-CoV-2疫苗。
