Abstract：
BACKGROUND: Neuropsychological testing is a mandatory component in the evaluation of drug resistant epilepsy. The results of testing may assist with both the localization of an epilepsy as well as assessment of surgical risk. Previous studies have demonstrated differences in the neuropsychological performance of patients with epilepsy and functional seizures. We hypothesized that comorbid functional seizures could potentially influence neuropsychological test performance. Therefore, we evaluated whether there is a difference in the neuropsychological test results between drug resistant epilepsy patients with and without comorbid functional seizures.
METHODS: Neuropsychological test results were compared between 25 patients with drug resistant focal epilepsy and 25 patients that also had documented functional seizures. Univariate analyses and multiple logistic regression models were used to both assess performance differences between the groups and to assess whether test results could be used to accurately identify which patients had comorbid functional seizures.
RESULTS: Epilepsy patients with comorbid functional seizures performed significantly worse on the FAS Verbal Fluency Test compared to ES patients (p = 0.047). Digit Span Backwards (p = 0.10), Digit Span Forwards (p = 0.14) and Working Memory Index (p = 0.10) tended to be lower in the epilepsy and functional seizures group but was not statistically significant. A multiple logistic regression model using the results of four neuropsychological tests was able to identify patients with comorbid functional seizures with 83.33% accuracy.
CONCLUSIONS: There are appeared to be some differences in the neuropsychological performance among drug resistant epilepsy patients based on whether they have comorbid functional seizures. These findings may have relevant implications for the interpretation of neuropsychological test results.
METHODS: Neuropsychological test results were compared between 25 patients with drug resistant focal epilepsy and 25 patients that also had documented functional seizures. Univariate analyses and multiple logistic regression models were used to both assess performance differences between the groups and to assess whether test results could be used to accurately identify which patients had comorbid functional seizures.
RESULTS: Epilepsy patients with comorbid functional seizures performed significantly worse on the FAS Verbal Fluency Test compared to ES patients (p = 0.047). Digit Span Backwards (p = 0.10), Digit Span Forwards (p = 0.14) and Working Memory Index (p = 0.10) tended to be lower in the epilepsy and functional seizures group but was not statistically significant. A multiple logistic regression model using the results of four neuropsychological tests was able to identify patients with comorbid functional seizures with 83.33% accuracy.
CONCLUSIONS: There are appeared to be some differences in the neuropsychological performance among drug resistant epilepsy patients based on whether they have comorbid functional seizures. These findings may have relevant implications for the interpretation of neuropsychological test results.
摘要：
背景：神经心理学测试是评估耐药性癫痫的强制性组成部分。测试结果可能有助于癫痫的定位以及手术风险的评估。先前的研究表明，癫痫和功能性癫痫发作患者的神经心理学表现存在差异。我们假设合并症功能性癫痫发作可能会影响神经心理学测试表现。因此,我们评估了有或没有合并功能性癫痫发作的耐药癫痫患者的神经心理学测试结果是否存在差异.
方法：比较了25例耐药局灶性癫痫患者和25例也有功能性癫痫发作记录的患者的神经心理学测试结果。使用单变量分析和多元逻辑回归模型来评估组间的表现差异，并评估测试结果是否可用于准确识别哪些患者患有合并症功能性癫痫发作。
结果：与ES患者相比，在FAS言语流畅度测试中，并发功能性癫痫发作的癫痫患者表现明显更差（p=0.047）。数字跨度向后（p=0.10），癫痫和功能性癫痫发作组的数字跨度（p=0.14）和工作记忆指数（p=0.10）趋于较低，但无统计学意义。使用四个神经心理学测试结果的多元逻辑回归模型能够以83.33％的准确率识别并发功能性癫痫发作的患者。
结论：耐药性癫痫患者的神经心理学表现似乎存在一些差异，这取决于他们是否患有共病功能性癫痫发作。这些发现可能对神经心理学测试结果的解释具有相关意义。
方法：比较了25例耐药局灶性癫痫患者和25例也有功能性癫痫发作记录的患者的神经心理学测试结果。使用单变量分析和多元逻辑回归模型来评估组间的表现差异，并评估测试结果是否可用于准确识别哪些患者患有合并症功能性癫痫发作。
结果：与ES患者相比，在FAS言语流畅度测试中，并发功能性癫痫发作的癫痫患者表现明显更差（p=0.047）。数字跨度向后（p=0.10），癫痫和功能性癫痫发作组的数字跨度（p=0.14）和工作记忆指数（p=0.10）趋于较低，但无统计学意义。使用四个神经心理学测试结果的多元逻辑回归模型能够以83.33％的准确率识别并发功能性癫痫发作的患者。
结论：耐药性癫痫患者的神经心理学表现似乎存在一些差异，这取决于他们是否患有共病功能性癫痫发作。这些发现可能对神经心理学测试结果的解释具有相关意义。
