PDF(Pubmed)
Abstract：
UNASSIGNED: The burden of carbapenem-resistant gram-negative bacteria (CRGNB) among solid organ transplant (SOT) recipients has not been systematically explored. Here, we discern the risk factors associated with CRGNB infection and colonization in SOT recipients.
UNASSIGNED: This study included observational studies conducted among CRGNB-infected SOT patients, which reported risk factors associated with mortality, infection or colonization. Relevant records will be searched in PubMed, Embase and Web of Science for the period from the time of database construction to 1 March 2023.
UNASSIGNED: A total of 23 studies with 13,511 participants were included, enabling the assessment of 27 potential risk factors. The pooled prevalence of 1-year mortality among SOT recipients with CRGNB was 44.5%. Prolonged mechanical ventilation, combined transplantation, reoperation and pre-transplantation CRGNB colonization are salient contributors to the occurrence of CRGNB infections in SOT recipients. Renal replacement therapy, post-LT CRGNB colonization, pre-LT liver disease and model for end-stage liver disease score increased the risk of infection. Re-transplantation, carbapenem use before transplantation and ureteral stent utilization increaesd risk of CRGNB colonization.
UNASSIGNED: Our study demonstrated that SOT recipients with CRGNB infections had a higher mortality risk. Invasive procedure may be the main factor contribute to CRGNB infection.
UNASSIGNED: This study included observational studies conducted among CRGNB-infected SOT patients, which reported risk factors associated with mortality, infection or colonization. Relevant records will be searched in PubMed, Embase and Web of Science for the period from the time of database construction to 1 March 2023.
UNASSIGNED: A total of 23 studies with 13,511 participants were included, enabling the assessment of 27 potential risk factors. The pooled prevalence of 1-year mortality among SOT recipients with CRGNB was 44.5%. Prolonged mechanical ventilation, combined transplantation, reoperation and pre-transplantation CRGNB colonization are salient contributors to the occurrence of CRGNB infections in SOT recipients. Renal replacement therapy, post-LT CRGNB colonization, pre-LT liver disease and model for end-stage liver disease score increased the risk of infection. Re-transplantation, carbapenem use before transplantation and ureteral stent utilization increaesd risk of CRGNB colonization.
UNASSIGNED: Our study demonstrated that SOT recipients with CRGNB infections had a higher mortality risk. Invasive procedure may be the main factor contribute to CRGNB infection.
摘要：
■尚未系统地研究实体器官移植（SOT）受者中耐碳青霉烯类革兰氏阴性菌（CRGNB）的负担。这里,我们发现了与CRGNB感染和SOT接受者定植相关的危险因素。
■这项研究包括在CRGNB感染的SOT患者中进行的观察性研究，报告了与死亡率相关的危险因素，感染或定植。相关记录将在PubMed中搜索，Embase和WebofScience，从数据库建设时间到2023年3月1日。
■共纳入23项研究，13,511名参与者，能够评估27个潜在风险因素。有CRGNB的SOT受者中1年死亡率的合并患病率为44.5%。长时间的机械通气,联合移植,再次手术和移植前CRGNB定植是SOT受者发生CRGNB感染的重要因素。肾脏替代疗法,LT后CRGNB定殖，LT前肝病和终末期肝病模型评分增加感染风险。重新移植,移植前使用碳青霉烯和输尿管支架的使用增加了CRGNB定植的风险。
■我们的研究表明，患有CRGNB感染的SOT接受者有更高的死亡风险。侵入性操作可能是导致CRGNB感染的主要因素。
■这项研究包括在CRGNB感染的SOT患者中进行的观察性研究，报告了与死亡率相关的危险因素，感染或定植。相关记录将在PubMed中搜索，Embase和WebofScience，从数据库建设时间到2023年3月1日。
■共纳入23项研究，13,511名参与者，能够评估27个潜在风险因素。有CRGNB的SOT受者中1年死亡率的合并患病率为44.5%。长时间的机械通气,联合移植,再次手术和移植前CRGNB定植是SOT受者发生CRGNB感染的重要因素。肾脏替代疗法,LT后CRGNB定殖，LT前肝病和终末期肝病模型评分增加感染风险。重新移植,移植前使用碳青霉烯和输尿管支架的使用增加了CRGNB定植的风险。
■我们的研究表明，患有CRGNB感染的SOT接受者有更高的死亡风险。侵入性操作可能是导致CRGNB感染的主要因素。
