Abstract：
OBJECTIVE: Small fiber neuropathy (SFN) is a subtype of painful neuropathies defined by dysfunction of the Aδ and unmyelinated C fibers. It presents with both neuropathic pain and dysautonomia symptoms, posing a significant diagnostic and therapeutic challenge. To address this challenge, research has been conducted to identify autoantibodies and define their association with phenotypes.
METHODS: Eleven cases of anti-plexin-D1 seropositive SFN were reviewed, along with relevant literature, in attempt to better define anti-plexin-D1 SFN demographics, symptoms, associated medical conditions, and therapeutics.
RESULTS: Anti-plexin-D1 SFN typically presents in female patients, with neuropathic pain, normal skin biopsy findings, and normal nerve conduction studies. Anti-plexin-D1 shows an association with concurrent chronic pain, with almost half of the patients undergoing an interventional procedure.
CONCLUSIONS: Anti-plexin-D1 represents a unique subgroup of SFN, defined by distinct demographics, phenotype, biopsy findings, and therapeutic management.
METHODS: Eleven cases of anti-plexin-D1 seropositive SFN were reviewed, along with relevant literature, in attempt to better define anti-plexin-D1 SFN demographics, symptoms, associated medical conditions, and therapeutics.
RESULTS: Anti-plexin-D1 SFN typically presents in female patients, with neuropathic pain, normal skin biopsy findings, and normal nerve conduction studies. Anti-plexin-D1 shows an association with concurrent chronic pain, with almost half of the patients undergoing an interventional procedure.
CONCLUSIONS: Anti-plexin-D1 represents a unique subgroup of SFN, defined by distinct demographics, phenotype, biopsy findings, and therapeutic management.
摘要：
目的：小纤维神经病（SFN）是由Aδ和无髓鞘C纤维功能障碍定义的疼痛性神经病的一种亚型。它同时表现为神经性疼痛和自主神经障碍症状，构成了重大的诊断和治疗挑战。为了应对这一挑战，已经进行了研究以鉴定自身抗体并确定其与表型的关联.
方法：回顾了11例抗plexin-D1血清表达阳性的SFN，连同相关文献，为了更好地定义抗丛蛋白D1SFN人口统计学，症状,相关的医疗条件，和治疗学。
结果：抗丛蛋白D1SFN通常出现在女性患者中，伴有神经性疼痛，正常皮肤活检结果，和正常的神经传导研究.抗丛蛋白D1显示与并发慢性疼痛有关，几乎一半的患者接受介入治疗。
结论：Anti-plexin-D1代表SFN的独特亚组，由不同的人口统计学定义，表型,活检结果，和治疗管理。
方法：回顾了11例抗plexin-D1血清表达阳性的SFN，连同相关文献，为了更好地定义抗丛蛋白D1SFN人口统计学，症状,相关的医疗条件，和治疗学。
结果：抗丛蛋白D1SFN通常出现在女性患者中，伴有神经性疼痛，正常皮肤活检结果，和正常的神经传导研究.抗丛蛋白D1显示与并发慢性疼痛有关，几乎一半的患者接受介入治疗。
结论：Anti-plexin-D1代表SFN的独特亚组，由不同的人口统计学定义，表型,活检结果，和治疗管理。
