METHODS: Eleven cases of anti-plexin-D1 seropositive SFN were reviewed, along with relevant literature, in attempt to better define anti-plexin-D1 SFN demographics, symptoms, associated medical conditions, and therapeutics.
RESULTS: Anti-plexin-D1 SFN typically presents in female patients, with neuropathic pain, normal skin biopsy findings, and normal nerve conduction studies. Anti-plexin-D1 shows an association with concurrent chronic pain, with almost half of the patients undergoing an interventional procedure.
CONCLUSIONS: Anti-plexin-D1 represents a unique subgroup of SFN, defined by distinct demographics, phenotype, biopsy findings, and therapeutic management.
方法:回顾了11例抗plexin-D1血清表达阳性的SFN,连同相关文献,为了更好地定义抗丛蛋白D1SFN人口统计学,症状,相关的医疗条件,和治疗学。
结果:抗丛蛋白D1SFN通常出现在女性患者中,伴有神经性疼痛,正常皮肤活检结果,和正常的神经传导研究.抗丛蛋白D1显示与并发慢性疼痛有关,几乎一半的患者接受介入治疗。
结论:Anti-plexin-D1代表SFN的独特亚组,由不同的人口统计学定义,表型,活检结果,和治疗管理。