Abstract：
Hepatitis E virus (HEV) persists in the male genital tract that associates with infertility. However, the presence of HEV in the female genital tract is unreported. Vaginal secretions, cervical smears, and cervix uteri were collected to explore the presence of HEV in the female genital tract. HEV RNA and/or antigens were detected in the vaginal secretions, cervical smears, and the cervix uteri of women. The infectivity of HEV excreted into vaginal secretions was further validated in vitro. In addition, HEV replicates in the female genital tract were identified in HEV-infected animal models by vaginal injection or vaginal mucosal infection to imitate sexual transmission. Serious genital tract damage and inflammatory responses with significantly elevated mucosal innate immunity were observed in women or animals with HEV vaginal infection. Results demonstrated HEV replicates in the female genital tract and causes serious histopathological damage and inflammatory responses.
摘要：
戊型肝炎病毒（HEV）在男性生殖道中持续存在，与不育症有关。然而,未报告女性生殖道中HEV的存在。阴道分泌物,宫颈涂片,收集子宫颈以探索HEV在女性生殖道中的存在。在阴道分泌物中检测到HEVRNA和/或抗原，宫颈涂片,还有女性的子宫颈.在体外进一步验证了HEV排泄到阴道分泌物中的感染性。此外,通过阴道注射或阴道粘膜感染以模仿性传播，在HEV感染的动物模型中鉴定出HEV在女性生殖道中的复制。在患有HEV阴道感染的妇女或动物中观察到严重的生殖道损伤和炎症反应以及显着升高的粘膜先天免疫。结果显示HEV在女性生殖道中复制并引起严重的组织病理学损伤和炎症反应。
