Lung adenocarcinoma is a common type of lung cancer with a high incidence and death rate. However, clinical indicators that effectively identify lung adenocarcinoma patients are still lacking. The protein encoded by the MECOM gene is a DNA-binding protein regulating gene expression, which has been found to play a cancer-promoting role in many cancers, but we found that it may play a cancer-suppressing role in lung adenocarcinoma. This study aimed to confirm whether MECOM can be a predictor for lung adenocarcinoma. Our results showed that lung adenocarcinoma patients had lower serum MECOM levels than healthy people, and patients with lower MECOM levels had a shorter survival rate. That is, patients with lower serum MECOM levels may indicate a high risk of developing lung adenocarcinoma and death. Thus, the MECOM gene is expected to be a predictor associated with the risk of developing lung adenocarcinoma and death.
肺腺癌是肺癌的一种常见类型,具有很高的发病率和死亡率。然而,目前仍缺乏有效鉴别肺腺癌患者的临床指标。MECOM基因编码的蛋白质是调节基因表达的DNA结合蛋白,已发现在许多癌症中发挥促癌作用,但是我们发现它可能在肺腺癌中起抑癌作用。本研究旨在证实MECOM是否可以作为肺腺癌的预测因子。我们的结果表明,肺腺癌患者的血清MECOM水平低于健康人,MECOM水平较低的患者生存率较短。也就是说,血清MECOM水平较低的患者可能提示发生肺腺癌和死亡的风险较高.因此,MECOM基因有望成为与肺腺癌和死亡风险相关的预测因子.