In this study, a protein called SMYD1 was examined in the adipose tissue of mice to understand its role in the development of different types of fat cells. The authors used mice fed a high-fat diet or mice exposed to a cold environment. The experiments were also performed on cultured cells that were stimulated to form specific types of fat cells (white adipocytes, which store energy; or beige adipocytes, which are responsible for releasing energy in the form of heat). The study found that SMYD1 increased in white adipose tissue particularly in response to cold exposure and high-fat diet, suggesting involvement in body temperature regulation. SMYD1 was higher in beige adipocytes than in white fat cells, and when SMYD1 was reduced, there was a decrease in certain factors related to energy control. Overall, these results suggest that SMYD1 plays a novel role in energy regulation in adipose tissues.
在这项研究中,在小鼠的脂肪组织中检测了一种称为SMYD1的蛋白质,以了解其在不同类型脂肪细胞发育中的作用。作者使用高脂肪饮食的小鼠或暴露于寒冷环境的小鼠。实验还在培养的细胞上进行,这些细胞被刺激以形成特定类型的脂肪细胞(白色脂肪细胞,储存能量;或米色脂肪细胞,它们负责以热的形式释放能量)。研究发现,SMYD1在白色脂肪组织中增加,特别是在寒冷暴露和高脂肪饮食的反应中,提示参与体温调节。米色脂肪细胞的SMYD1高于白色脂肪细胞,当SMYD1减少时,与能量控制相关的某些因素有所减少。总的来说,这些结果表明,SMYD1在脂肪组织的能量调节中起着新的作用。