PDF(Pubmed)
Abstract：
Since the leprosy cases have fallen dramatically, the incidence of leprosy has remained stable over the past years, indicating that multidrug therapy seems unable to eradicate leprosy. More seriously, the emergence of rifampicin-resistant strains also affects the effectiveness of treatment. Immunoprophylaxis was mainly carried out through vaccination with the BCG but also included vaccines such as LepVax and MiP. Meanwhile, it is well known that the infection and pathogenesis largely depend on the host\'s genetic background and immunity, with the onset of the disease being genetically regulated. The immune process heavily influences the clinical course of the disease. However, the impact of immune processes and genetic regulation of leprosy on pathogenesis and immunological levels is largely unknown. Therefore, we summarize the latest research progress in leprosy treatment, prevention, immunity and gene function. The comprehensive research in these areas will help elucidate the pathogenesis of leprosy and provide a basis for developing leprosy elimination strategies.
摘要：
由于麻风病病例急剧下降，麻风病的发病率在过去几年一直保持稳定，表明多药治疗似乎无法根除麻风病。更严重的是,利福平耐药菌株的出现也会影响治疗的有效性.免疫预防主要通过BCG疫苗接种进行，但也包括LepVax和MiP等疫苗。同时,众所周知，感染和发病机制在很大程度上取决于宿主的遗传背景和免疫力，疾病的发作是由基因调控的。免疫过程严重影响疾病的临床进程。然而,麻风病的免疫过程和遗传调控对发病机制和免疫水平的影响在很大程度上是未知的。因此,总结麻风病治疗的最新研究进展,预防,免疫和基因功能。这些领域的综合研究将有助于阐明麻风病的发病机制，并为制定麻风病消除策略提供依据。
