PDF(Pubmed)
Abstract：
Glomangiopericytoma (GPC) is a rare benign sinonasal tumor originating from Zimmerman\'s Pericytes surrounding capillaries and accounting for less than 0.05% of all sinonasal tumors. Glomangiopericytoma has low malignant potential (5-10%) and is mostly diagnosed in the 6th or 7th decade of age with slight female preponderance. We presented here a case series of 5 patients with sinonasal GPC. This research was conducted at a tertiary healthcare centre in North India. In our case series, all the patients were evaluated and underwent endoscopic surgical resection. All patients underwent digital subtraction angiography (DSA) and preoperative embolization. The coblation technique used for haemostasis proved very effective and time-saving. All patients exhibited cytoplasmic SMA positivity (a marker of GPC) and CD34 negativity, while one patient exhibited a high Ki-67 index (> 10%), which is a predictor of aggressive tumor behavior. None of the patients showed any recurrence in follow-up. We recommend performing complete endoscopic surgical excision to prevent recurrence. The use of DSA, preoperative embolization, and intraoperative use of the coblation technique provides a cleaner surgical field and reduced operating time.
摘要：
血管外皮细胞瘤（GPC）是一种罕见的良性鼻窦肿瘤，起源于Zimmerman毛细血管周围的周细胞，占所有鼻窦肿瘤的0.05％以下。血管外皮细胞瘤具有较低的恶性可能性（5-10％），并且主要在6岁或7岁时被诊断出，女性略有优势。我们在这里介绍了5例鼻窦GPC患者的病例系列。这项研究是在印度北部的三级医疗保健中心进行的。在我们的案例系列中，所有患者均接受评估并接受内镜手术切除.一切患者均行数字减影血管造影(DSA)及术前栓塞。用于止血的消融术被证明非常有效且节省时间。所有患者均显示细胞质SMA阳性（GPC的标志物）和CD34阴性，而一名患者表现出较高的Ki-67指数（>10%），这是侵袭性肿瘤行为的预测指标。随访中无一例患者出现复发。我们建议进行完整的内窥镜手术切除以防止复发。DSA的使用，术前栓塞,术中使用消融术技术提供了一个更清洁的手术领域和减少的手术时间。
