PDF(Pubmed)
Abstract：
Non-ossifying fibroma (NOF) of jaw bones are rare. While NOF is the most common benign bone tumor of long bones with pathognomonic radiological features and bear a tendency for self-regression, gnathic NOF appears to be comparatively larger in size and behave more aggressively. A 16 years old female patient reported with painless swelling of the right side of the face of 4 months duration. Radiographic analysis showed a unilocular radiolucent lesion of right angle of the mandible with ill-defined margins, cortical perforation and thinning of inferior border. The lesion was provisionally diagnosed as odontogenic keratocyst/unicystic ameloblastoma and incisional biopsy was performed. The histopathological features and immunohistochemical characteristics favored a diagnosis of NOF. The lesion was excised and reconstructed. The excised specimen confirmed the diagnosis. There are no signs of recurrence at 18 months follow-up. NOF should be considered in the differential diagnosis of uni-/multilocular radiolucencies of jaws particularly the posterior mandible.
摘要：
颌骨的非骨化性纤维瘤（NOF）很少见。虽然NOF是最常见的长骨良性骨肿瘤，具有病理放射学特征，并具有自回归的趋势。颌骨NOF的大小似乎相对较大，行为更积极。一名16岁女性患者报告面部右侧无痛性肿胀4个月。影像学分析显示下颌骨直角的单眼射线可透病变，边缘不明确，皮质穿孔和下边界变薄。暂时诊断为牙源性角化囊肿/单囊性成釉细胞瘤，并进行了切开活检。组织病理学特征和免疫组织化学特征有利于NOF的诊断。切除并重建病变。切除的标本证实了诊断。随访18个月无复发迹象。在颌骨的单/多房性放射性的鉴别诊断中，尤其是后下颌骨，应考虑NOF。
