PDF(Pubmed)
Abstract：
SARS COV 2 infection affects primarily the respiratory system and various organs in humans is responsible for higher mortality secondary to cytokine storm during the COVID-19 pandemic. It affects the internal auditory system is responsible for Sensory neural hearing loss in adults as well as children born to COVID-19 infected mothers. This study was aimed to detect the pattern of hearing loss in COVID-19 infected adults and pattern of hearing loss in children born to gestational COVID-19 infected mothers. Fifty asymptomatic RT-PCR COVID-19 infected adults and age, sex matched healthy controls were evaluated for audiological profile using Pure Tone Audiometry (PTA). Children born to COVID-19 infected mothers were tested using Transient product otoacoustic emissions and click-evoked auditory brainstem responses (ABRs) compared with children born to non-COVID mothers. PTA auditory profile of COVID-19 infected adults on day 7 had 30% (16 out of 50) significant high frequency sensory neural hearing impairment for 4000 Hz (p value 0.003), 6000 Hz (p value 0.001), 8000 Hz (p value 0.001). Repeat PTA testing on day 30 showed normal hearing. Whereas in children, 40% (n = 20) born to COVID-19 infected mothers had OAE as \"Refer\". BERA (ABRs) testing of that OAE \"Refer\" children revealed 30% (n = 6) hearing impairment. COVID-19 infection cause transient type of high frequency sensory neural hearing loss in adults. Whereas in children born to COVID-19 infected mothers there is risk of developing permanent, progressive or long-standing transient type of sensory neural hearing loss.
摘要：
SARSCOV2感染主要影响人类的呼吸系统和各种器官，是COVID-19大流行期间细胞因子风暴继发的较高死亡率的原因。它影响内部听觉系统，是成人和感染COVID-19的母亲所生的儿童感觉神经性听力损失的原因。这项研究旨在检测感染COVID-19的成年人的听力损失模式和妊娠感染COVID-19的母亲所生的儿童的听力损失模式。50名无症状RT-PCR感染COVID-19的成年人和年龄，使用纯音测听法（PTA）评估性别匹配的健康对照的听力学特征。与非COVID母亲所生的孩子相比，使用瞬态产品耳声发射和点击诱发听觉脑干反应（ABR）对感染COVID-19的母亲所生的孩子进行了测试。在第7天感染COVID-19的成年人的PTA听觉特征在4000Hz（p值0.003）时，有30％（50个中的16个）明显的高频感觉神经听力障碍，6000Hz（p值0.001），8000Hz（p值0.001）。在第30天重复PTA测试显示听力正常。而在儿童中，40%(n=20)感染COVID-19的母亲出生的OAE为“参考”。BERA（ABRs）对OAE“参考”儿童的测试显示30％（n=6）听力障碍。COVID-19感染导致成人短暂性高频感觉神经听力损失。而在感染COVID-19的母亲所生的孩子中，有发展为永久性的风险，进行性或长期短暂的感觉神经听力损失。
