PDF(Pubmed)
Abstract：
UNASSIGNED: Stress cardiomyopathy (Takotsubo syndrome) defined as Takotsubo syndrome is defined as a reversible acute myocardial syndrome with myocardial injury with regional wall motion abnormality and no coronary explanations in the context of stress. The pathophysiology remains partially unknown, and these cases are probably underestimated in paediatrics. We report six cases of Takotsubo probably secondary to neurological damage.
UNASSIGNED: Six patients (10, 13, 16, 10, and 9 years and 5 months) presented with haemodynamic lability with echocardiography data leading to suspicion of Takotsubo syndrome. These cases were secondary to neurological involvement (cerebral haemorrhage, intraventricular haemorrhage, brain damage due to bifrontal oedema, posterior fossa tumour, pneumococcal meningitis, high-grade glioma). All patients were rapidly started on amine. Reversibility of the acute myocardial syndrome was complete in all but one child, who rapidly progressed to encephalic death.
UNASSIGNED: Neurological distress has been suggested as a potential cause of Takotsubo syndrome. The pathophysiology is possibly related to excessive stimulation of the sympathetic system. This syndrome should probably be considered in the setting of left heart failure with neurological distress so as not to delay the use of amines especially since in the paediatric population the probability of a coronary origin is low.
UNASSIGNED: Six patients (10, 13, 16, 10, and 9 years and 5 months) presented with haemodynamic lability with echocardiography data leading to suspicion of Takotsubo syndrome. These cases were secondary to neurological involvement (cerebral haemorrhage, intraventricular haemorrhage, brain damage due to bifrontal oedema, posterior fossa tumour, pneumococcal meningitis, high-grade glioma). All patients were rapidly started on amine. Reversibility of the acute myocardial syndrome was complete in all but one child, who rapidly progressed to encephalic death.
UNASSIGNED: Neurological distress has been suggested as a potential cause of Takotsubo syndrome. The pathophysiology is possibly related to excessive stimulation of the sympathetic system. This syndrome should probably be considered in the setting of left heart failure with neurological distress so as not to delay the use of amines especially since in the paediatric population the probability of a coronary origin is low.
摘要：
■定义为Takotsubo综合征的应激性心肌病（Takotsubo综合征）被定义为可逆性急性心肌综合征，伴有局部壁运动异常的心肌损伤，在压力背景下没有冠状动脉解释。病理生理学仍然部分未知，这些病例可能在儿科中被低估了。我们报告了6例Takotsubo可能继发于神经系统损害。
■6例患者（10、13、16、10和9岁零5个月）表现为血流动力学不稳定，超声心动图数据导致怀疑Takotsubo综合征。这些病例继发于神经系统受累（脑出血，脑室内出血，由于双额叶水肿导致的脑损伤,后颅窝肿瘤，肺炎球菌性脑膜炎,高级别神经胶质瘤)。所有患者都迅速开始使用胺。急性心肌综合征的可逆性在除了一个孩子之外的所有孩子中都是完全的，迅速进展为脑死亡。
■神经系统疾病被认为是Takotsubo综合征的潜在原因。病理生理学可能与交感神经系统的过度刺激有关。在患有神经系统疾病的左心衰竭的情况下，应该考虑这种综合征，以免延迟胺的使用，尤其是因为在儿科人群中，冠状动脉起源的可能性很低。
■6例患者（10、13、16、10和9岁零5个月）表现为血流动力学不稳定，超声心动图数据导致怀疑Takotsubo综合征。这些病例继发于神经系统受累（脑出血，脑室内出血，由于双额叶水肿导致的脑损伤,后颅窝肿瘤，肺炎球菌性脑膜炎,高级别神经胶质瘤)。所有患者都迅速开始使用胺。急性心肌综合征的可逆性在除了一个孩子之外的所有孩子中都是完全的，迅速进展为脑死亡。
■神经系统疾病被认为是Takotsubo综合征的潜在原因。病理生理学可能与交感神经系统的过度刺激有关。在患有神经系统疾病的左心衰竭的情况下，应该考虑这种综合征，以免延迟胺的使用，尤其是因为在儿科人群中，冠状动脉起源的可能性很低。
