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Abstract：
Metabolic syndrome (MetS) is on the rise in developing countries and is characterized by a series of indications of metabolic disturbance. However, the prevalence of MetS varies under different definitions. The study aimed to compare five definitions of MetS in the China adult population, to explore their prevalence, characteristics and agreement.
The data for the retrospective study came from the China Health and Retirement Longitudinal Study (CHARLS), consisting of 9,588 participants (≥45). MetS definitions from International Diabetes Federation (IDF) (2006), National Cholesterol Education Program Adult Treatment Panel III (ATPIII) (2005), National Cholesterol Education Program Adult Treatment Panel III (ATPIII) (2001), Chinese Diabetes society (CDS) (2004) and the World Health Organization (WHO) (1999). We used binary and multivariable logistic analysis to explore factors connected with MetS.
The five definitions of MetS led to different prevalence of MetS:34.52% by IDF (2006), 38.63% by ATP (2005), 25.94% by ATP (2001), 26.31% by CDS (2004), 21.57% by WHO (1999). According to the definition of IDF (2006) (22.32% vs. 45.06%), ATPIII (2005) definition (27.99% vs. 47.82%), ATPIII (2001) definition (15.37% vs. 35.07%), CDS (2004) definition (19.96% vs. 31.80%), and WHO (1999) definition (17.44% vs. 25.14%), the prevalence of MetS in men was low but in women was high. The agreement between the five definitions for men was good except for the IDF (2006) definition and ATPIII (2001) definition (kappa = 0.51), with kappa values from 0.64 to 0.85. For women, the agreement between the five definitions was good ranging from 0.67 to 0.95, however, except for the definition of CDS (2004) and the definition of IDF (2006) (kappa = 0.44), the definition of WHO (1999) and the definition of IDF (2006) (kappa = 0.55), and the definition of WHO (1999) and the definition of ATPIII (2005) (kappa = 0.54). Binary logistic analysis indicated that although the impact and relevance varied by sex and definition, age, education, marital status, current residence, current smoking, alcohol using, taking activities and number of chronic diseases were factors connected to MetS.
the prevalence and characteristics of the five definitions of MetS are different in the Chinese population. Therefore, it is vital to use the same definition for a country to diagnose MetS. On the other side, a lower prevalence in men than in women and the consistency of five MetS definitions are good in men but relatively poor in women.
The data for the retrospective study came from the China Health and Retirement Longitudinal Study (CHARLS), consisting of 9,588 participants (≥45). MetS definitions from International Diabetes Federation (IDF) (2006), National Cholesterol Education Program Adult Treatment Panel III (ATPIII) (2005), National Cholesterol Education Program Adult Treatment Panel III (ATPIII) (2001), Chinese Diabetes society (CDS) (2004) and the World Health Organization (WHO) (1999). We used binary and multivariable logistic analysis to explore factors connected with MetS.
The five definitions of MetS led to different prevalence of MetS:34.52% by IDF (2006), 38.63% by ATP (2005), 25.94% by ATP (2001), 26.31% by CDS (2004), 21.57% by WHO (1999). According to the definition of IDF (2006) (22.32% vs. 45.06%), ATPIII (2005) definition (27.99% vs. 47.82%), ATPIII (2001) definition (15.37% vs. 35.07%), CDS (2004) definition (19.96% vs. 31.80%), and WHO (1999) definition (17.44% vs. 25.14%), the prevalence of MetS in men was low but in women was high. The agreement between the five definitions for men was good except for the IDF (2006) definition and ATPIII (2001) definition (kappa = 0.51), with kappa values from 0.64 to 0.85. For women, the agreement between the five definitions was good ranging from 0.67 to 0.95, however, except for the definition of CDS (2004) and the definition of IDF (2006) (kappa = 0.44), the definition of WHO (1999) and the definition of IDF (2006) (kappa = 0.55), and the definition of WHO (1999) and the definition of ATPIII (2005) (kappa = 0.54). Binary logistic analysis indicated that although the impact and relevance varied by sex and definition, age, education, marital status, current residence, current smoking, alcohol using, taking activities and number of chronic diseases were factors connected to MetS.
the prevalence and characteristics of the five definitions of MetS are different in the Chinese population. Therefore, it is vital to use the same definition for a country to diagnose MetS. On the other side, a lower prevalence in men than in women and the consistency of five MetS definitions are good in men but relatively poor in women.
摘要：
■代谢综合征（MetS）在发展中国家呈上升趋势，其特征是代谢紊乱的一系列适应症。然而,MetS的患病率在不同的定义下不同。本研究旨在比较中国成年人口中MetS的五种定义，探索它们的患病率，特点和协议。
■回顾性研究的数据来自中国健康与退休纵向研究（CHARLS），由9,588名参与者组成（≥45名）。来自国际糖尿病联合会(IDF)的MetS定义(2006)，国家胆固醇教育计划成人治疗小组III（ATPIII）（2005年），国家胆固醇教育计划成人治疗小组III(ATPIII)(2001年)，中国糖尿病学会(CDS)(2004)和世界卫生组织(WHO)(1999)。我们使用二元和多变量逻辑分析来探索与MetS相关的因素。
■MetS的五个定义导致MetS的患病率不同：IDF（2006年）为34.52％，ATP（2005年）38.63%，25.94%的ATP（2001），CDS（2004年）26.31%，世卫组织为21.57%(1999年)。根据IDF(2006)的定义(22.32%vs.45.06%），ATPIII(2005)定义(27.99%与47.82%），ATPIII(2001)定义(15.37%与35.07%)，CDS(2004)定义(19.96%与31.80%），和WHO(1999)的定义(17.44%vs.25.14%），男性的MetS患病率较低,但女性的患病率较高.除IDF（2006）定义和ATPIII（2001）定义（kappa=0.51）外，男性的五个定义之间的一致性很好，Kappa值从0.64到0.85。对女人来说,这五个定义之间的一致性从0.67到0.95很好，但是，除了CDS(2004)的定义和IDF(2006)的定义(Kappa=0.44)，世界卫生组织的定义（1999年）和IDF的定义（2006年）（Kappa=0.55），以及WHO(1999)和ATPIII(2005)的定义(kappa=0.54)。二元逻辑分析表明，尽管影响和相关性因性别和定义而异，年龄,教育,婚姻状况,现居,目前吸烟,酒精使用,活动和慢性病数量是与MetS相关的因素。
■在中国人群中，MetS的五个定义的患病率和特征是不同的。因此,对于一个国家来说，使用相同的定义来诊断MetS是至关重要的。在另一边,男性的患病率低于女性,且5个MetS定义的一致性在男性中良好,但在女性中相对较差.
■回顾性研究的数据来自中国健康与退休纵向研究（CHARLS），由9,588名参与者组成（≥45名）。来自国际糖尿病联合会(IDF)的MetS定义(2006)，国家胆固醇教育计划成人治疗小组III（ATPIII）（2005年），国家胆固醇教育计划成人治疗小组III(ATPIII)(2001年)，中国糖尿病学会(CDS)(2004)和世界卫生组织(WHO)(1999)。我们使用二元和多变量逻辑分析来探索与MetS相关的因素。
■MetS的五个定义导致MetS的患病率不同：IDF（2006年）为34.52％，ATP（2005年）38.63%，25.94%的ATP（2001），CDS（2004年）26.31%，世卫组织为21.57%(1999年)。根据IDF(2006)的定义(22.32%vs.45.06%），ATPIII(2005)定义(27.99%与47.82%），ATPIII(2001)定义(15.37%与35.07%)，CDS(2004)定义(19.96%与31.80%），和WHO(1999)的定义(17.44%vs.25.14%），男性的MetS患病率较低,但女性的患病率较高.除IDF（2006）定义和ATPIII（2001）定义（kappa=0.51）外，男性的五个定义之间的一致性很好，Kappa值从0.64到0.85。对女人来说,这五个定义之间的一致性从0.67到0.95很好，但是，除了CDS(2004)的定义和IDF(2006)的定义(Kappa=0.44)，世界卫生组织的定义（1999年）和IDF的定义（2006年）（Kappa=0.55），以及WHO(1999)和ATPIII(2005)的定义(kappa=0.54)。二元逻辑分析表明，尽管影响和相关性因性别和定义而异，年龄,教育,婚姻状况,现居,目前吸烟,酒精使用,活动和慢性病数量是与MetS相关的因素。
■在中国人群中，MetS的五个定义的患病率和特征是不同的。因此,对于一个国家来说，使用相同的定义来诊断MetS是至关重要的。在另一边,男性的患病率低于女性,且5个MetS定义的一致性在男性中良好,但在女性中相对较差.
