Abstract：
Objective: Nasopharyngeal melanoma is a rare mucosal malignant melanoma with high recurrence rate, metastasis rate and vascular invasion rate. In this paper, we report a case of primary nasopharyngeal mucosal melanoma. Methods: A case of primary nasopharyngeal mucosal melanoma was reported, and its clinical symptoms, pathological characteristics, treatment and follow-up were described in detail. Results: This report describes a 59-year-old male patient with persistent nasal congestion and suspected malignant nasopharyngeal neoplasm. Patients receive surgical resection and adjuvant radiotherapy after complete resection. Imaging studies showed no tissue invasion or lymph node metastases. The results of immunohistochemistry were Melan-A(+), HMB45(+), and S100(+). The final diagnosis was malignant nasopharyngeal melanoma. After 2 years of follow-up, the prognosis was good, and there was no metastasis or recurrence. Discussion: Nasopharyngeal melanoma is a rare malignancy with a poor prognosis, and surgical resection is the mainstay of treatment. Postoperative adjuvant therapy can improve the rate of local control of lesions. Early diagnosis and thorough examination are extremely important for the patient\'s prognosis.
摘要：
目的:鼻咽黑色素瘤是一种罕见的黏膜恶性黑色素瘤,复发率高,转移率和血管浸润率。在本文中,我们报告一例原发性鼻咽粘膜黑色素瘤。方法:报道1例原发性鼻咽粘膜黑色素瘤,和它的临床症状，病理特征，治疗和随访进行了详细描述。结果：本报告描述了一名59岁的男性患者，患有持续的鼻充血和可疑的恶性鼻咽肿瘤。患者在完全切除后接受手术切除和辅助放疗。影像学检查显示无组织浸润或淋巴结转移。免疫组化结果为Melan-A(+),HMB45(+),S100(+)最终诊断为恶性鼻咽黑色素瘤。经过2年的随访，预后良好,无转移或复发。讨论：鼻咽黑色素瘤是一种罕见的恶性肿瘤，预后不良，手术切除是治疗的主要手段。术后辅助治疗可提高病灶局部控制率。早期诊断和全面检查对患者的预后极为重要。
