Abstract：
UNASSIGNED: Obesity has been associated with an increased risk of reproductive failure, especially preterm birth. As preimplantation genetic testing for aneuploidies (PGT-A) is increasingly used worldwide, however, it is still unclear whether body mass index (BMI) has an effect on the preterm birth rate in patients undergoing in vitro fertilization (IVF) with PGT-A when transferring a single euploid blastocyst.
UNASSIGNED: This retrospective, single-center cohort study included 851 women who underwent the first cycle of frozen-thawed single euploid blastocyst transfer with PGT-A between 2015 and 2020. The primary outcome was the preterm birth rate. Secondary outcomes were clinical pregnancy, miscarriage, ectopic pregnancy, pregnancy complications, and live birth.
UNASSIGNED: Patients were grouped by World Health Organization (WHO) BMI class: underweight (<18.5, n = 81), normal weight (18.5-24.9, n = 637), overweight (25-30, n = 108), and obese (≥30, n = 25). There was no difference in the clinical pregnancy, miscarriage, ectopic pregnancy, pregnancy complication, and live birth by BMI category. In multivariate logistic regression analysis, preterm birth rates were significantly higher in women with overweight (adjusted odds ratio [aOR] 3.18; 95% confidence interval [CI], 1.29-7.80, p = .012) and obese (aOR 1.49; 95% CI, 1.03-12.78, p = .027) compared with the normal weight reference group.
UNASSIGNED: Women with obesity experience a higher rate of preterm birth after euploid embryo transfer than women with a normal weight, suggesting that the negative impact of obesity on IVF and clinical outcomes may be related to other mechanisms than aneuploidy.
UNASSIGNED: This retrospective, single-center cohort study included 851 women who underwent the first cycle of frozen-thawed single euploid blastocyst transfer with PGT-A between 2015 and 2020. The primary outcome was the preterm birth rate. Secondary outcomes were clinical pregnancy, miscarriage, ectopic pregnancy, pregnancy complications, and live birth.
UNASSIGNED: Patients were grouped by World Health Organization (WHO) BMI class: underweight (<18.5, n = 81), normal weight (18.5-24.9, n = 637), overweight (25-30, n = 108), and obese (≥30, n = 25). There was no difference in the clinical pregnancy, miscarriage, ectopic pregnancy, pregnancy complication, and live birth by BMI category. In multivariate logistic regression analysis, preterm birth rates were significantly higher in women with overweight (adjusted odds ratio [aOR] 3.18; 95% confidence interval [CI], 1.29-7.80, p = .012) and obese (aOR 1.49; 95% CI, 1.03-12.78, p = .027) compared with the normal weight reference group.
UNASSIGNED: Women with obesity experience a higher rate of preterm birth after euploid embryo transfer than women with a normal weight, suggesting that the negative impact of obesity on IVF and clinical outcomes may be related to other mechanisms than aneuploidy.
摘要：
■肥胖与生殖失败的风险增加有关，尤其是早产。随着非整倍体的植入前基因检测（PGT-A）在全球范围内越来越多地使用，然而,目前尚不清楚体重指数(BMI)对接受PGT-A体外受精(IVF)的患者移植单个整倍体囊胚时的早产率是否有影响.
■这次回顾展，单中心队列研究包括851名女性,她们在2015年至2020年间接受了PGT-A冻融单整倍体囊胚移植的第一个周期.主要结果是早产率。次要结果是临床妊娠，流产,异位妊娠,妊娠并发症,和活产。
■患者按世界卫生组织（WHO）BMI等级分组：体重不足（<18.5，n=81），正常体重（18.5-24.9，n=637），超重（25-30，n=108），肥胖（≥30，n=25）。临床妊娠没有差异，流产,异位妊娠,妊娠并发症,和按BMI类别划分的活产。在多变量逻辑回归分析中，超重女性的早产率明显更高(调整后比值比[aOR]3.18;95%置信区间[CI],1.29-7.80，p=.012）和肥胖（aOR1.49；95％CI，1.03-12.78，p=.027）与正常体重参考组相比。
肥胖女性在整倍体胚胎移植后比体重正常的女性早产率更高，这表明肥胖对IVF和临床结局的负面影响可能与非整倍体以外的其他机制有关.
■这次回顾展，单中心队列研究包括851名女性,她们在2015年至2020年间接受了PGT-A冻融单整倍体囊胚移植的第一个周期.主要结果是早产率。次要结果是临床妊娠，流产,异位妊娠,妊娠并发症,和活产。
■患者按世界卫生组织（WHO）BMI等级分组：体重不足（<18.5，n=81），正常体重（18.5-24.9，n=637），超重（25-30，n=108），肥胖（≥30，n=25）。临床妊娠没有差异，流产,异位妊娠,妊娠并发症,和按BMI类别划分的活产。在多变量逻辑回归分析中，超重女性的早产率明显更高(调整后比值比[aOR]3.18;95%置信区间[CI],1.29-7.80，p=.012）和肥胖（aOR1.49；95％CI，1.03-12.78，p=.027）与正常体重参考组相比。
肥胖女性在整倍体胚胎移植后比体重正常的女性早产率更高，这表明肥胖对IVF和临床结局的负面影响可能与非整倍体以外的其他机制有关.
