PDF(Pubmed)
Abstract：
BACKGROUND: Adhering to varenicline has been shown to significantly improve the chances of successfully quitting smoking, with studies indicating a twofold increase in 6-month quit rates. However, despite its potential benefits, many individuals struggle with maintaining good adherence to varenicline; thus there is a need to develop scalable strategies to help people adhere. As a first step to inform the development of an intervention to improve adherence to varenicline, we conducted a rapid literature review to identify: 1) modifiable barriers and facilitators to varenicline adherence, and 2) behaviour change techniques associated with increased adherence to varenicline.
METHODS: We searched MEDLINE, Embase, APA PsycINFO, CINAHL, and the Cochrane Central Register of Controlled Trials for relevant studies published between 2006 and 2022. Search terms included \"varenicline,\" \"smoking cessation,\" and \"adherence,\" and their respective subject headings and synonyms. We screened and included studies reporting modifiable determinants of adherence to varenicline and then assessed quality, extracted modifiable determinants and mapped them to the Theoretical Domains Framework version 2 and the Behaviour Change Technique Taxonomy version 1.
RESULTS: A total of 1,221 titles were identified through the database searches; 61 met the eligibility criteria. Most of the studies were randomized controlled trials and predominantly focused on barriers to varenicline. Only nine studies explicitly mentioned behaviour change techniques used to help varenicline adherence. Eight domains were identified as barriers to varenicline adherence (behavioural regulation, memory, goals, intentions, beliefs about capabilities, beliefs about consequences, optimism/pessimism, and environmental context) and five as facilitators (knowledge, behavioural regulation, beliefs about capabilities, social influences, and environmental context).
CONCLUSIONS: This study identifies barriers and facilitators that should be addressed when developing a complex adherence intervention tailored to patients\' needs based on modifiable determinants of medication adherence, some of which are under- used by existing adherence interventions. The findings from this review will inform the design of a theory-based healthbot planned to improve varenicline adherence in people undergoing smoking cessation treatment.
BACKGROUND: This study was registered with PROSPERO (# CRD42022321838).
METHODS: We searched MEDLINE, Embase, APA PsycINFO, CINAHL, and the Cochrane Central Register of Controlled Trials for relevant studies published between 2006 and 2022. Search terms included \"varenicline,\" \"smoking cessation,\" and \"adherence,\" and their respective subject headings and synonyms. We screened and included studies reporting modifiable determinants of adherence to varenicline and then assessed quality, extracted modifiable determinants and mapped them to the Theoretical Domains Framework version 2 and the Behaviour Change Technique Taxonomy version 1.
RESULTS: A total of 1,221 titles were identified through the database searches; 61 met the eligibility criteria. Most of the studies were randomized controlled trials and predominantly focused on barriers to varenicline. Only nine studies explicitly mentioned behaviour change techniques used to help varenicline adherence. Eight domains were identified as barriers to varenicline adherence (behavioural regulation, memory, goals, intentions, beliefs about capabilities, beliefs about consequences, optimism/pessimism, and environmental context) and five as facilitators (knowledge, behavioural regulation, beliefs about capabilities, social influences, and environmental context).
CONCLUSIONS: This study identifies barriers and facilitators that should be addressed when developing a complex adherence intervention tailored to patients\' needs based on modifiable determinants of medication adherence, some of which are under- used by existing adherence interventions. The findings from this review will inform the design of a theory-based healthbot planned to improve varenicline adherence in people undergoing smoking cessation treatment.
BACKGROUND: This study was registered with PROSPERO (# CRD42022321838).
摘要：
背景：已证明坚持varenicline可以显着提高成功戒烟的机会，研究表明，6个月的戒烟率增加了两倍。然而,尽管它有潜在的好处，许多人努力保持良好的varenicline;因此有必要制定可扩展的策略来帮助人们坚持。作为制定干预措施以提高对伐尼克兰的依从性的第一步，我们进行了快速的文献综述，以确定：1)伐尼克兰依从性的可修改的障碍和促进因素，和2）与增加对伐尼克兰的依从性相关的行为改变技术。
方法：我们搜索了MEDLINE，Embase,APAPsycINFO,CINAHL,以及2006年至2022年间发表的相关研究的Cochrane中央对照试验登记册。搜索词包括“varenicline，\"\"戒烟,“和”坚持，“及其各自的主题词和同义词。我们筛选并纳入报告可修改的伐尼克兰依从性决定因素的研究，然后评估质量，提取可修改的决定因素，并将它们映射到理论域框架版本2和行为改变技术分类版本1。
结果：通过数据库搜索确定了1,221个标题；61个符合资格标准。大多数研究是随机对照试验，主要集中在伐尼克兰的障碍上。只有9项研究明确提到了用于帮助伐尼克兰依从性的行为改变技术。八个领域被确定为伐尼克兰依从性的障碍(行为调节，记忆,目标,意图,关于能力的信念，关于后果的信念，乐观/悲观，和环境背景)和五个作为促进者(知识，行为调节，关于能力的信念，社会影响,和环境背景)。
结论：本研究确定了在根据药物依从性的可修改决定因素制定针对患者需求的复杂依从性干预措施时应解决的障碍和促进因素。其中一些未被现有的依从性干预措施充分利用。这项审查的结果将为基于理论的健康机器人的设计提供信息，该机器人计划改善接受戒烟治疗的人的伐尼克兰依从性。
背景：本研究注册于PROSPERO（#CRD42022321838）。
方法：我们搜索了MEDLINE，Embase,APAPsycINFO,CINAHL,以及2006年至2022年间发表的相关研究的Cochrane中央对照试验登记册。搜索词包括“varenicline，\"\"戒烟,“和”坚持，“及其各自的主题词和同义词。我们筛选并纳入报告可修改的伐尼克兰依从性决定因素的研究，然后评估质量，提取可修改的决定因素，并将它们映射到理论域框架版本2和行为改变技术分类版本1。
结果：通过数据库搜索确定了1,221个标题；61个符合资格标准。大多数研究是随机对照试验，主要集中在伐尼克兰的障碍上。只有9项研究明确提到了用于帮助伐尼克兰依从性的行为改变技术。八个领域被确定为伐尼克兰依从性的障碍(行为调节，记忆,目标,意图,关于能力的信念，关于后果的信念，乐观/悲观，和环境背景)和五个作为促进者(知识，行为调节，关于能力的信念，社会影响,和环境背景)。
结论：本研究确定了在根据药物依从性的可修改决定因素制定针对患者需求的复杂依从性干预措施时应解决的障碍和促进因素。其中一些未被现有的依从性干预措施充分利用。这项审查的结果将为基于理论的健康机器人的设计提供信息，该机器人计划改善接受戒烟治疗的人的伐尼克兰依从性。
背景：本研究注册于PROSPERO（#CRD42022321838）。
