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Abstract：
Although the assessment of the amniotic fluid volume in pregnancy is part of the fetal wellbeing surveillance, the impact of idiopathic polyhydramnios (IP) on maternal and perinatal outcomes in unknown. The aim of this meta-analysis was to investigate the association of IP with different maternal and perinatal outcomes. We screened five electronic databases until December 2023 and performed data extraction and quality assessment using ROBINS-E in duplicates. Pooled risk ratios and 95% confidence intervals (95% CI) were calculated with a random effects model. 38 studies were included. Patients with IP were at increased risk of perinatal complications including preterm delivery (RR 1.96, 95% CI 1.35-2.86; I2 = 92%), placental abruption (RR 3.20, 95% CI 2.20-4.65; I2 = 2%), delivery via caesarean section (RR 1.60, 95% CI 1.39-1.84; I2 = 95%) and postpartum haemorrhage (RR 1.98, 95% CI 1.22-3.22; I2 = 84%). Similarly, IP was associated with increased risk of adverse perinatal outcomes including low APGAR score (RR 3.0, 95% CI 1.23-7.35; I2 = 95%), stillbirth (RR 4.75, 95% CI 2.54-8.86; I2 = 9%) and perinatal mortality (RR 4.75, 95% CI 2.67-8.48; I2 = 37%). This meta-analysis suggests that pregnant women with IP may be at increased risk of perinatal complications and adverse neonatal outcomes. However, data remains inconclusive considering the low quality and high heterogeneity of included studies.PROSPERO registration number: CRD42022359944.
摘要：
尽管评估妊娠羊水量是胎儿健康监测的一部分，特发性羊水过多（IP）对孕产妇和围产期结局的影响未知。这项荟萃分析的目的是调查IP与不同的孕产妇和围产期结局的关系。我们筛选了五个电子数据库，直到2023年12月，并使用ROBINS-E重复进行数据提取和质量评估。使用随机效应模型计算集合风险比和95%置信区间(95%CI)。共纳入38项研究。IP患者围产期并发症的风险增加，包括早产（RR1.96，95%CI1.35-2.86；I2=92%），胎盘早剥（RR3.20，95%CI2.20-4.65；I2=2%），经剖宫产分娩(RR1.60,95%CI1.39-1.84;I2=95%)和产后出血(RR1.98,95%CI1.22-3.22;I2=84%).同样，IP与不良围产期结局的风险增加相关，包括低APGAR评分（RR3.0，95%CI1.23-7.35；I2=95%），死产(RR4.75,95%CI2.54-8.86;I2=9%)和围产期死亡率(RR4.75,95%CI2.67-8.48;I2=37%)。这项荟萃分析表明，患有IP的孕妇可能会增加围产期并发症和不良新生儿结局的风险。然而,考虑到纳入研究的低质量和高异质性,数据仍无定论.PROSPERO注册号：CRD42022359944。
