Abstract：
OBJECTIVE: To compare topical nonsteroidal anti-inflammatory drug (NSAID) efficacy on intravitreal injection-induced pain reduction and determine the most efficient topical NSAID.
METHODS: This randomized-controlled study included 662 eyes of 662 patients. Based on the types of NSAID administered before intravitreal injection, eight subgroups were formed. In the control group, a sterile saline solution was applied instead of NSAIDs. The visual analog scale was used to assess pain scores after intravitreal injection. The visual analog scale scores were noted immediately and 6 hours following injection (sixth hour).
RESULTS: Nepafenac 0.3%, nepafenac 0.1%, and bromfenac 0.09% had the lowest scores, immediately after and after 6 hours, with no significant differences. Diclofenac and ketorolac had higher visual analog scale scores than the first trio but lower scores than the control group. Flurbiprofen, pranoprofen, and indomethacin did not significantly affect immediate pain; however, at the sixth hour, the visual analog scale scores were significantly reduced.
CONCLUSIONS: Nepafenac 0.3%, nepafenac 0.1%, and bromfenac 0.09% were the most effective NSAIDs for pain reduction. Although some NSAIDs did not have a significant effect on immediate pain, they all provided significant benefits at the sixth hour.
METHODS: This randomized-controlled study included 662 eyes of 662 patients. Based on the types of NSAID administered before intravitreal injection, eight subgroups were formed. In the control group, a sterile saline solution was applied instead of NSAIDs. The visual analog scale was used to assess pain scores after intravitreal injection. The visual analog scale scores were noted immediately and 6 hours following injection (sixth hour).
RESULTS: Nepafenac 0.3%, nepafenac 0.1%, and bromfenac 0.09% had the lowest scores, immediately after and after 6 hours, with no significant differences. Diclofenac and ketorolac had higher visual analog scale scores than the first trio but lower scores than the control group. Flurbiprofen, pranoprofen, and indomethacin did not significantly affect immediate pain; however, at the sixth hour, the visual analog scale scores were significantly reduced.
CONCLUSIONS: Nepafenac 0.3%, nepafenac 0.1%, and bromfenac 0.09% were the most effective NSAIDs for pain reduction. Although some NSAIDs did not have a significant effect on immediate pain, they all provided significant benefits at the sixth hour.
摘要：
目的：比较局部非甾体抗炎药（NSAID）对玻璃体内注射（IVI）引起的疼痛减轻的疗效，并确定最有效的局部NSAID。
方法：这项随机对照研究包括662例患者的662只眼。根据在IVI之前给药的NSAID的类型，组成了八个小组。在对照组中，使用无菌盐水溶液代替NSAIDs.采用视觉模拟量表(VAS)评估IVI后疼痛评分。立即和注射后6小时(第6小时)记录VAS评分。
结果：Nepafenac0.3%，0.1%,溴芬酸得分最低,在6小时之后和之后，没有显著差异。双氯芬酸和酮咯酸的VAS评分高于第一三重奏组，但低于对照组。氟比洛芬,普拉洛芬,和吲哚美辛没有显著影响即时疼痛;然而，在第六个小时，VAS评分显著降低.
结论：尼泊尔帕芬克0.3%，0.1%,和溴芬酸是减轻疼痛最有效的NSAIDs。虽然一些NSAIDs对即时疼痛没有显著影响，他们都在第6小时提供了显着的好处。
方法：这项随机对照研究包括662例患者的662只眼。根据在IVI之前给药的NSAID的类型，组成了八个小组。在对照组中，使用无菌盐水溶液代替NSAIDs.采用视觉模拟量表(VAS)评估IVI后疼痛评分。立即和注射后6小时(第6小时)记录VAS评分。
结果：Nepafenac0.3%，0.1%,溴芬酸得分最低,在6小时之后和之后，没有显著差异。双氯芬酸和酮咯酸的VAS评分高于第一三重奏组，但低于对照组。氟比洛芬,普拉洛芬,和吲哚美辛没有显著影响即时疼痛;然而，在第六个小时，VAS评分显著降低.
结论：尼泊尔帕芬克0.3%，0.1%,和溴芬酸是减轻疼痛最有效的NSAIDs。虽然一些NSAIDs对即时疼痛没有显著影响，他们都在第6小时提供了显着的好处。
