Abstract：
BACKGROUND: Acute pancreatitis is a common cause of hospitalizations in the United States, causing approximately 230 000 to 275 000 annual admissions We present the case of a patient with acute pancreatitis likely due to doxycycline.
METHODS: A 64-year-old male was admitted after developing acute epigastric pain radiating to his back, a lipase of 6611 (units/L), and a computed tomography scan showing moderate peripancreatic inflammation. He had no recent alcohol use, his gallbladder was surgically absent, and he had no gallbladder pathology on evaluation; however, he had been started on doxycycline 10 days prior. While hospitalized, he was treated with pain medications, fluids, and antibiotics for aspiration pneumonia. His acute symptoms resolved, except for minor intermittent abdominal pain 2 months after discharge.
CONCLUSIONS: Doxycycline-induced pancreatitis has been reported within 3 to 17 days of medication initiation. Given the temporal correlation and lack of other inciting etiologies, we determined the most likely etiology was doxycycline.
CONCLUSIONS: Further study is needed to understand the pathophysiology and incidence of doxycycline-induced pancreatitis.
METHODS: A 64-year-old male was admitted after developing acute epigastric pain radiating to his back, a lipase of 6611 (units/L), and a computed tomography scan showing moderate peripancreatic inflammation. He had no recent alcohol use, his gallbladder was surgically absent, and he had no gallbladder pathology on evaluation; however, he had been started on doxycycline 10 days prior. While hospitalized, he was treated with pain medications, fluids, and antibiotics for aspiration pneumonia. His acute symptoms resolved, except for minor intermittent abdominal pain 2 months after discharge.
CONCLUSIONS: Doxycycline-induced pancreatitis has been reported within 3 to 17 days of medication initiation. Given the temporal correlation and lack of other inciting etiologies, we determined the most likely etiology was doxycycline.
CONCLUSIONS: Further study is needed to understand the pathophysiology and incidence of doxycycline-induced pancreatitis.
摘要：
背景：急性胰腺炎是美国住院的常见原因，导致每年约230000至275000年入院我们介绍了可能由于多西环素导致的急性胰腺炎患者的情况。
方法：一名64岁男性因背部急性上腹痛而入院，6611（单位/L）的脂肪酶，计算机断层扫描显示中度胰腺周围炎症。他最近没有饮酒，他的胆囊没有手术，他在评估时没有胆囊病理学；然而，他在10天前开始使用多西环素。住院期间，他接受了止痛药治疗，流体,和吸入性肺炎的抗生素。他的急性症状缓解了,出院后2个月轻微间歇性腹痛除外。
结论：据报道，多西环素诱导的胰腺炎在开始用药后3至17天内。鉴于时间相关性和缺乏其他煽动性病因，我们确定最可能的病因是多西环素.
结论：需要进一步研究以了解多西环素诱导的胰腺炎的病理生理学和发病率。
方法：一名64岁男性因背部急性上腹痛而入院，6611（单位/L）的脂肪酶，计算机断层扫描显示中度胰腺周围炎症。他最近没有饮酒，他的胆囊没有手术，他在评估时没有胆囊病理学；然而，他在10天前开始使用多西环素。住院期间，他接受了止痛药治疗，流体,和吸入性肺炎的抗生素。他的急性症状缓解了,出院后2个月轻微间歇性腹痛除外。
结论：据报道，多西环素诱导的胰腺炎在开始用药后3至17天内。鉴于时间相关性和缺乏其他煽动性病因，我们确定最可能的病因是多西环素.
结论：需要进一步研究以了解多西环素诱导的胰腺炎的病理生理学和发病率。
